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Biodistribution of Amikacin Solid Lipid Nanoparticles After Pulmonary Delivery Publisher Pubmed



Varshosaz J1 ; Ghaffari S2 ; Mirshojaei SF3 ; Jafarian A4 ; Atyabi F5 ; Kobarfard F6 ; Azarmi S7
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, P.O. Box 14155-6451, Iran
  2. 2. RandD and Quality Control Department, Iranian Parenteral and Pharmaceutical Co., Tehran, P.O. Box 18735-568, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, P.O. Box 14155-6451, Iran
  4. 4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, P.O. Box 14155-6451, Iran
  5. 5. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, P.O. Box 14155-6451, Iran
  6. 6. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, P.O. Box 14155-6153, Iran
  7. 7. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada

Source: BioMed Research International Published:2013


Abstract

The main purpose of the present work was studying the biodistribution of amikacin solid lipid nanoparticles (SLNs) after pulmonary delivery to increase its concentration in the lungs for treatment of cystic fibrosis lung infections and also providing a new method for clinical application of amikacin. To achieve this aim, 99mTc labelled amikacin was loaded in cholesterol SLNs and after in vitro optimization, the desired SLNs and free drug were administered through pulmonary and i.v. routes to male rats and qualitative and biodistribution studies were done. Results showed that pulmonary delivery of SLNs of amikacin by microsprayer caused higher drug concentration in lungs than kidneys while i.v. administration of free drug caused reverse conditions. It seems that pulmonary delivery of SLNs may improve patients' compliance due to reduction of drug side effects in kidneys and elongation of drug dosing intervals due to the sustained drug release from SLNs. © 2013 J. Varshosaz et al.
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