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Fatal Disseminated Aspergillosis in an Immunocompetent Patient With Covid-19 Due to Aspergillus Ochraceus Publisher Pubmed



Hakamifard A1 ; Hashemi M2 ; Fakhim H1 ; Aboutalebian S3 ; Hajiahmadi S4 ; Mohammadi R1, 3
Authors
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Authors Affiliations
  1. 1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pulmonology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Medical Mycology Published:2021


Abstract

Aspergillus infection is a well-known complication of severe influenza and severe acute respiratory syndrome coronavirus (SARS-CoV), and these infections have been related with significant morbidity and mortality even when appropriately diagnosed and treated. Recent studies have indicated that SARS-CoV-2 might increase the risk of invasive pulmonary aspergillosis (IPA). Here, we report the first case of Aspergillus ochraceus in a SARS-CoV-2 positive immunocompetent patient, which is complicated by pulmonary and brain infections. Proven IPA is supported by the positive Galactomannan test, culture-positive, and histopathological evidence. The patient did not respond to voriconazole, and liposomal amphotericin B was added to his anti-fungal regimen. Further studies are needed to evaluate the prevalence of IPA in immunocompetent patients infected with SARS-CoV-2. Consequently, testing for the incidence of Aspergillus species in lower respiratory secretions and Galactomannan test of COVID-19 patients with appropriate therapy and targeted anti-fungal therapy based on the primary clinical suspicion of IPA are highly recommended. © 2021 Elsevier Masson SAS
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