Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Decreased Phosphatidate Phosphohydrolase Activity in the Liver of Rats Exposed to Nicotinic Acid, Clofibrate and Gemfibrozil



Haghighi B1 ; Kashani Z1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Indian Journal of Pharmacology Published:1999

Abstract

Objective: To investigate whether nicotinic acid, gemfibrozil and clofibrate exert their hypolipidemic effect by changing the activity of hepatic phosphatide phosphohydrolase (PAP). Methods: Male Wistar rats were intraperitoneally treated with one of the following: nicotinic acid, clofibrate, gemfibrozil, corresponding vehicle. All animals were given corn oil (p.o.) 2 h before injection. They were sacrificed at different time intervals and PAP enzyme activity was measured in liver homogenate. Serum triacylglycerol and cholesterol levels were also estimated. Results: Nicotinic acid inhibited PAP activity 35% with simultaneous decrease in serum triacylglycerol (29%) and cholesterol (22%) concentrations. Clofibrate also inhibited PAP activity (31%) with parallel decline in the concentrations of triacylglycerol (26%) and cholesterol (19%). Similar patterns were observed in rats injected with gemfibrozil in which the fall in PAP activity, triacylglycerol and cholesterol concentrations were 17%, 43% and 12% respectively. Conclusion: Hypolipemic effects of these compounds are, at least in part, resulted from inhibition of hepatic PAP activity, a key enzyme in the lipid metabolism.
Related Docs
View other Related Docs
1. Possible Involvement of Hepatic Phosphatidate Phosphohydrolase in the Mechanisms of Actions of Certain Antilipemic Drugs in Rats, Iranian Journal of Pharmaceutical Research (2007)
2. Efficiency of Black Cumin Seeds on Hematological Factors in Normal and Hypercholesterolemic Rabbits, ARYA Atherosclerosis (2012)
3. The Effects of Olive Oil and Cholesterol Enriched Diets on Aortic Fatty Streak Development and Lipid Peroxidation in Rabbits, Nutrition and Health (2022)
4. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
5. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
6. The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals, African Journal of Pharmacy and Pharmacology (2011)
7. Lipid Lowering by Hydroalcoholic Extracts of Amaranthus Caudatus L. Induces Regression of Rabbits Atherosclerotic Lesions, Lipids in Health and Disease (2011)
8. Hypolipidemic Activity of Anethum Graveolens in Rats, Phytotherapy Research (2008)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (15)
Gholamreza Dashti (4)
Other Related Docs
9. The Postprandial Effect of Apple Juice Intake on Some of the Biochemical Risk Factors of Atherosclerosis in Male Rabbit, Journal of Medicinal Plants Research (2009)
10. Effect of Glycyrrhiza Glabra Extract on Aorta Wall Atherosclerotic Lesion in Hypercholesterolemic Rabbits, Pakistan Journal of Nutrition (2007)
11. Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum Pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats, Iranian Journal of Pharmaceutical Research (2009)
12. Liver and Serum Lipids in Wistar Rats Fed a Novel Structured Lipid Containing Conjugated Linoleic Acid and Conjugated Linolenic Acid; [Lipidos Hepaticos Y Sericos En Ratas Wistar Alimentadas Con Nuevos Lipidos Estructurados Que Con-Tienen Acido Linoleico Conjugado Y Acido Linolenico Conjugado.], Grasas y Aceites (2019)
13. Effect of Gundelia Tournefortii L. on Some Cardiovascular Risk Factors in an Animal Model, Journal of HerbMed Pharmacology (2017)
14. Anti-Hyperelipidemic Effects of Sumac (Rhus Coriaria L.): Can Sumac Strengthen Anti-Hyperlipidemic Effect of Statins?, Der Pharmacia Lettre (2016)
15. Anethum Graveolens and Hyperlipidemia: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2014)
16. Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats, Iranian Biomedical Journal (2001)
17. Effect of Hydroalcoholic Extract of Hypericum Perforatum on Selected Traditional and Novel Biochemical Factors of Cardiovascular Diseases and Atherosclerotic Lesions in Hypercholesterolemic Rabbits: A Comparison Between the Extract and Lovastatin, Journal of Pharmacy and Bioallied Sciences (2012)
18. Antihyperlipidemic Effect of Hydroalcoholic Extract, and Polyphenolic Fraction From Dracocephalum Kotschyi Boiss, Pharmaceutica Acta Helvetiae (1998)
19. Hypocholesterolemic Effects of Purslane Extract on Serum Lipids in Rabbits Fed With High Cholesterol Levels, International Journal of Pharmacology (2007)
20. Evidence for Histidine Residues on Plasma Membrane Phosphatidate Phosphohydrolase From Rat Liver, Iranian Journal of Basic Medical Sciences (2008)
21. Nigella Sativa L. Improves Lipid Profile and Prevents Atherosclerosis: Evidence From an Experimental Study on Hypercholesterolemic Rabbits, Journal of Functional Foods (2013)
22. Oral Carnitine Supplementation for Dyslipidemia in Chronic Hemodialysis Patients., Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2012)
23. Anti Atherosclerotic Effects of Verjuice on Hypocholesterolemic Rabbits, African Journal of Pharmacy and Pharmacology (2011)
24. Impact of Sumac on Postprandial High-Fat Oxidative Stress, Pakistan Journal of Medical Sciences (2013)
25. Effects of Cigarette Smoke, Nicotine and Cotinine on Red Blood Cell Hemolysis and Their -Sh Capacity, Experimental and Clinical Cardiology (2005)
26. Effects of Acute Verjuice Consumption With a High-Cholesterol Diet on Some Biochemical Risk Factors of Atherosclerosis in Rabbits, Medical Science Monitor (2010)
27. The Effects of Cornelian Cherry on Atherosclerosis and Atherogenic Factors in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2011)
28. The Impact of Pycnogenol Supplementation on Plasma Lipids in Humans: A Systematic Review and Meta-Analysis of Clinical Trials, Phytotherapy Research (2019)
29. Suppressive Impact of Anethum Graveolens Consumption on Biochemical Risk Factors of Atherosclerosis in Hypercholesterolemic Rabbits, International Journal of Preventive Medicine (2013)
30. Serum Paraoxonase 1 Activity Is Associated With Fatty Acid Composition of High Density Lipoprotein, Disease Markers (2013)