Platelet-Rich Plasma Versus Granulocyte Colony-Stimulating Factor in Addressing Recurrent Implantation Failure: A Randomized, Double-Blind Clinical Trial Publisher



Tehrani HG ; Mostajeran E ; Dehghanimohammadabadi R ; Naghshineh E
Source: Journal of Research in Medical Sciences Published:2026

Abstract

Background: The aim of the study is to evaluate the effect of platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor in addressing recurrent implantation failure. Materials and Methods: Fifty patients were randomly assigned to two treatment groups: PRP and granulocyte colony-stimulating factor (GCSF). All patients were followed up to 12 weeks after implantation. The rate of positive pregnancy tests (chemical pregnancy), implantation rate (clinical pregnancy), and pregnancy reaching 12 weeks old (ongoing pregnancy) in these two groups was compared. Results: Biochemical pregnancy, gestational sac formation, fetal heart formation, and 12-week pregnancy occurred in 6 (24%), 6 (24%), 6 (24%), and 5 women (20%) in the PRP group and occurred in 7 women (28%), 5 women (20%), 5 women (20%), and 5 women (20%) in the GCSF group. There was no statistically significant difference regarding biochemical pregnancy, gestational sac formation, fertile heart formation, and 12-week-old pregnancy between study groups (P = 0.747, 0.737, 0.737, and 1, respectively). Conclusion: Our study showed no difference in the efficacy of plasma-rich platelets and GCSFs in treating recurrent implantation failure. © 2026 Journal of Research in Medical Sciences.