Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases

Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases Publisher Pubmed

Sedaghat N¹ ; Etemadifar M²

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1. Alzahra Research Institute, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Multiple Sclerosis and Related Disorders Published:2022

Abstract

Chimeric antigen receptor (CAR) regulatory T cell (Treg) therapy has approved promising in murine experiments. It comprises from ex-vivo introduction of CARs to the Tregs of the recipient, and infusing them back thereafter. This process requires enormous amounts of equipment and expertise and therefore, cannot be considered feasible for people with demyelinating diseases, even if it proves to be effective and safe in the future. The presented novel concept introduces feasibility to CAR Treg therapy, by shifting most of the ex-vivo processes in-vivo. Inter-disciplinary discussions on such concepts is encouraged among experts in different fields. © 2021 Elsevier B.V.

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Abbas Rezaei (2)

Nafiseh Esmaeil (1)

Style	Citing Format
MLA	Sedaghat N, Etemadifar M. "Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases." Multiple Sclerosis and Related Disorders, vol. 57, no. , 2022, pp. -.
APA	Sedaghat N, Etemadifar M (2022). Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases. Multiple Sclerosis and Related Disorders, 57(), -.
Chicago	Sedaghat N, Etemadifar M. "Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases." Multiple Sclerosis and Related Disorders 57, no. (2022): -.
Harvard	Sedaghat N, Etemadifar M (2022) 'Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases', Multiple Sclerosis and Related Disorders, 57(), pp. -.
Vancouver	Sedaghat N, Etemadifar M. Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases. Multiple Sclerosis and Related Disorders. 2022;57():-.
BibTex	@article{ author = {Sedaghat N and Etemadifar M}, title = {Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases}, journal = {Multiple Sclerosis and Related Disorders}, volume = {57}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Sedaghat N AU - Etemadifar M TI - Inducing Chimeric Antigen Receptor (Car) Regulatory T Cells In-Vivo: A Novel Concept for a Potential Feasible Cure of Demyelinating Diseases JO - Multiple Sclerosis and Related Disorders VL - 57 IS - SP - EP - PY - 2022 ER -

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