As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice Publisher Pubmed

Summary: Research shows targeted gold nanoclusters boost radiation therapy for breast tumors, improving survival. #CancerTreatment #Nanotechnology

Ghahremani F^{1, 2} ; Kefayat A^{3, 4} ; Shahbazigahrouei D² ; Motaghi H⁵ ; Mehrgardi MA⁵ ; Haghjooyjavanmard S⁶
Source: Nanomedicine Published:2018

Abstract

Aim: Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer. Materials & methods: AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells targeting, radiosensitizing effect, tumor targeting, and biocompatibility in breast tumor-bearing mice. Results: Flow cytometry and fluorescence microscopy exhibited more cellular uptake for Apt-GNCs in comparison with GNCs. In addition, inductively coupled plasma optical emission spectrometry results demonstrated its effective tumor targeting as the tumors' gold content for GNCs and Apt-GNCs were 8.53 and 15.33 μg/g, respectively. Apt-GNCs significantly enhanced radiotherapy efficacy as mean tumors' volume decreased about 39% and 9 days increase in the mice survival was observed. Both GNCs and Apt-GNCs were biocompatible. Conclusion: The Apt-GNCs is a novel and efficient radiosensitizer. © 2018 2018 Future Medicine Ltd.