As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice

As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice Publisher Pubmed

Summary: Research shows targeted gold nanoclusters boost radiation therapy for breast tumors, improving survival. #CancerTreatment #Nanotechnology

Ghahremani F^{1, 2} ; Kefayat A^{3, 4} ; Shahbazigahrouei D² ; Motaghi H⁵ ; Mehrgardi MA⁵ ; Haghjooyjavanmard S⁶

Source: Nanomedicine Published:2018

Abstract

Aim: Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer. Materials & methods: AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells targeting, radiosensitizing effect, tumor targeting, and biocompatibility in breast tumor-bearing mice. Results: Flow cytometry and fluorescence microscopy exhibited more cellular uptake for Apt-GNCs in comparison with GNCs. In addition, inductively coupled plasma optical emission spectrometry results demonstrated its effective tumor targeting as the tumors' gold content for GNCs and Apt-GNCs were 8.53 and 15.33 μg/g, respectively. Apt-GNCs significantly enhanced radiotherapy efficacy as mean tumors' volume decreased about 39% and 9 days increase in the mice survival was observed. Both GNCs and Apt-GNCs were biocompatible. Conclusion: The Apt-GNCs is a novel and efficient radiosensitizer. © 2018 2018 Future Medicine Ltd.

Experts (# of related papers)

Daryoush Shahbazi-Gahrouei (1)

Shaghayegh Haghjooy Javanmard (1)

As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice

Style	Citing Format
MLA	Ghahremani F, et al.. "As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice." Nanomedicine, vol. 13, no. 20, 2018, pp. 2563-2578.
APA	Ghahremani F, Kefayat A, Shahbazigahrouei D, Motaghi H, Mehrgardi MA, Haghjooyjavanmard S (2018). As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice. Nanomedicine, 13(20), 2563-2578.
Chicago	Ghahremani F, Kefayat A, Shahbazigahrouei D, Motaghi H, Mehrgardi MA, Haghjooyjavanmard S. "As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice." Nanomedicine 13, no. 20 (2018): 2563-2578.
Harvard	Ghahremani F et al. (2018) 'As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice', Nanomedicine, 13(20), pp. 2563-2578.
Vancouver	Ghahremani F, Kefayat A, Shahbazigahrouei D, Motaghi H, Mehrgardi MA, Haghjooyjavanmard S. As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice. Nanomedicine. 2018;13(20):2563-2578.
BibTex	@article{ author = {Ghahremani F and Kefayat A and Shahbazigahrouei D and Motaghi H and Mehrgardi MA and Haghjooyjavanmard S}, title = {As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice}, journal = {Nanomedicine}, volume = {13}, number = {20}, pages = {2563-2578}, year = {2018} }
RIS	TY - JOUR AU - Ghahremani F AU - Kefayat A AU - Shahbazigahrouei D AU - Motaghi H AU - Mehrgardi MA AU - Haghjooyjavanmard S TI - As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice JO - Nanomedicine VL - 13 IS - 20 SP - 2563 EP - 2578 PY - 2018 ER -

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