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As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice Publisher Pubmed



Ghahremani F1, 2 ; Kefayat A3, 4 ; Shahbazigahrouei D2 ; Motaghi H5 ; Mehrgardi MA5 ; Haghjooyjavanmard S6
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Radiotherapy, Arak University of Medical Sciences, Arak, 38481-76941, Iran
  2. 2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. Department of Oncology, Seyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  5. 5. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran
  6. 6. Department of Physiology, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan, 81746-73461, Iran

Source: Nanomedicine Published:2018


Abstract

Aim: Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer. Materials & methods: AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells targeting, radiosensitizing effect, tumor targeting, and biocompatibility in breast tumor-bearing mice. Results: Flow cytometry and fluorescence microscopy exhibited more cellular uptake for Apt-GNCs in comparison with GNCs. In addition, inductively coupled plasma optical emission spectrometry results demonstrated its effective tumor targeting as the tumors' gold content for GNCs and Apt-GNCs were 8.53 and 15.33 μg/g, respectively. Apt-GNCs significantly enhanced radiotherapy efficacy as mean tumors' volume decreased about 39% and 9 days increase in the mice survival was observed. Both GNCs and Apt-GNCs were biocompatible. Conclusion: The Apt-GNCs is a novel and efficient radiosensitizer. © 2018 2018 Future Medicine Ltd.
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