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A Review of the Potential Adverse Health Impacts of Atrazine in Humans Publisher



Arabi S2 ; Heidaribeni M3 ; Poursafa P4 ; Roshanaei M5 ; Kelishadi R1
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
  5. 5. School of Pharmacy and Pharmaceutical Sciences, Islamic Azad University Pharmaceutical Sciences Branch, Tehran, Iran

Source: Reviews on Environmental Health Published:2024


Abstract

Atrazine is a widely used chlorinated triazine herbicide in agricultural settings, which has raised concerns over its potential adverse effects on human health. The extensive application of atrazine has resulted in its pervasive presence in the environment, contaminating soil, groundwater, and surface water. While earlier research suggested that atrazine is unlikely to pose a health concern, recent evidence has indicated the necessity to reassess this point of view. This review aims to assess the recent evidence on atrazine’s adverse effects on human health, focusing on (i) Cancer, (ii) Metabolic Diseases, (iii) Reproductive System, (iv) Neural System, and (v) Epigenetic Effects. Strategies to mitigate atrazine contamination and limitations of previous studies are also discussed. We strongly believe that further investigation is necessary to determine the potential detrimental consequences of atrazine in humans, particularly in developing countries, where herbicides are widely used without stringent safety regulations. Therefore, the current review will be beneficial for guiding future research and regulatory measures concerning the use of atrazine. © 2024 Walter de Gruyter GmbH. All rights reserved.
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