The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients

The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients Publisher Pubmed

Gheybi MK¹ ; Farrokhi S² ; Ravanbod MR³ ; Ostovar A⁴ ; Mehrzad V⁵ ; Nematollahi P⁶

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1. Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
2. Department of Immunology, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
3. Department of Hematology and Oncology, Bushehr University of Medical Sciences, Bushehr, Iran
4. Department of Epidemiology, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
5. Department of Hematology and Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
6. Department of Cancer Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Breast Cancer Published:2017

Abstract

Background: T regulatory cells (Tregs) are known to negatively control immune response. The frequency of these cells was inversely correlated with clinical outcomes of breast cancer. CD19+CD24hiCD38hi cells also play a critical role in inflammation and autoimmune disease. However, their function in tumor immune response is less studied. In this study we aimed to determine the role of CD19+CD24hiCD38hi cells and some other clinicopathological variables in increasing the proportion of Tregs in breast cancer patients. Methods: We selected 47 patients with invasive ductal breast carcinoma and 50 healthy controls and obtained their blood samples. Results: The proportion of circulating CD4+CD25+Foxp3+ Tregs and CD19+CD24hiCD38hi cells was significantly increased in breast cancer patients. We also found that increased proportion of Tregs in breast cancer is correlated with HER2 amplification, advanced clinical stages, serum TGF-β1 and increased CD19+CD24hiCD38hi cells in the peripheral blood. Conclusion: Altogether, our data suggest that as much as Tregs, CD19+CD24hiCD38hi B cells could also have a part in the suppression of immune response in breast cancer. © 2017, The Japanese Breast Cancer Society.

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Style	Citing Format
MLA	Gheybi MK, et al.. "The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients." Breast Cancer, vol. 24, no. 6, 2017, pp. 756-764.
APA	Gheybi MK, Farrokhi S, Ravanbod MR, Ostovar A, Mehrzad V, Nematollahi P (2017). The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients. Breast Cancer, 24(6), 756-764.
Chicago	Gheybi MK, Farrokhi S, Ravanbod MR, Ostovar A, Mehrzad V, Nematollahi P. "The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients." Breast Cancer 24, no. 6 (2017): 756-764.
Harvard	Gheybi MK et al. (2017) 'The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients', Breast Cancer, 24(6), pp. 756-764.
Vancouver	Gheybi MK, Farrokhi S, Ravanbod MR, Ostovar A, Mehrzad V, Nematollahi P. The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients. Breast Cancer. 2017;24(6):756-764.
BibTex	@article{ author = {Gheybi MK and Farrokhi S and Ravanbod MR and Ostovar A and Mehrzad V and Nematollahi P}, title = {The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients}, journal = {Breast Cancer}, volume = {24}, number = {6}, pages = {756-764}, year = {2017} }
RIS	TY - JOUR AU - Gheybi MK AU - Farrokhi S AU - Ravanbod MR AU - Ostovar A AU - Mehrzad V AU - Nematollahi P TI - The Correlation of Cd19 + Cd24 + Cd38 + B Cells and Other Clinicopathological Variables With the Proportion of Circulating Tregs in Breast Cancer Patients JO - Breast Cancer VL - 24 IS - 6 SP - 756 EP - 764 PY - 2017 ER -

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