Recurrent Multiple Myeloma Following Renal Transplantation: A Case Report Publisher Pubmed



Taheri D¹ ; Chehrei A¹ ; Fesharakizadeh M² ; Seyrafean S³ ; Shahidi S³ ; Emami A³ ; Taheri S³ ; Azani M⁴ Show Affiliations
Source: Transplantation Proceedings Published:2007

Abstract

Renal transplantation is generally not considered for patients with multiple myeloma (MM) because of their extremely poor prognosis. However, for patients in remission, it offers an alternative to dialysis. There are few reports of MM recurrence among kidney transplant recipients. We report a 57-year-old white man with end-stage renal disease (ESRD) and known multiple myeloma in remission who underwent kidney transplantation. Eighteen months after transplantation upon routine follow-up, he was observed to have an elevated creatinine with no evidence of recurrence of myeloma upon bone marrow aspiration. Light microscopy and immunoflorescence of a renal biopsy showed chronic scarring of the kidney owing to cast nephropathy consistent with MM recurrence. Repeat bone marrow aspiration 1 week later confirmed this diagnosis. A review of the literature of prior studies suggested that it is reasonable to perform renal transplantation in patients with ESRD due to MM in remission, but large prospective studies would help to develop a strategy for prevention of multiple myeloma recurrence. © 2007 Elsevier Inc. All rights reserved.