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The Effect of Vitamin D Supplementation on Body Composition in Nursing Mothers With Overweight or Obesity: A Randomized Double-Blind Placebo-Controlled Clinical Trial Publisher



Gerveieeha Z1 ; Siassi F1 ; Qorbani M2 ; Menbar RS3 ; Ahmadi MH4 ; Sotoudeh G1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Hojatdost street, Naderi street, Keshavarz Blvd, Tehran, Iran
  2. 2. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Laboratory Sciences, school of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

Source: BMC Nutrition Published:2023


Abstract

Background: This study aimed to evaluate the effect of vitamin D3 supplementation on body composition and anthropometric measures of nursing mothers. Methods: In a double-blind, randomized clinical trial, 90 nursing mothers with overweight or obesity were randomized into three groups for 12 weeks: two groups of vitamin D3 supplementation (2000 IU/d (VD1), n = 32 and 4000 IU/d (VD2), n = 29) and placebo (PL) group (n = 29). The information on body composition was obtained using the body impedance analysis (BIA) method. Serum 25-Hydroxy vitamin D (25(OH) D), Intact Parathyroid Hormone (iPTH), calcium, and phosphorus were measured before and after the intervention. Data were analyzed based on the intention-to-treat (ITT) method. Two-way repeated measure ANOVA (mixed ANOVA) was applied to assess whether the mean changes in the results from baseline to 12 weeks differ in the three groups. Results: There was a significant increase in the serum 25(OH) D concentration in the VD2 group compared to VD1 and PL groups (mean change (MC), 12.3 ng/ml; 95% CI, 9.4/15.0, p-value < 0.001). In addition, fat mass (MC, − 4.3 kg; 95% CI, − 7.0/− 1.1, p-value < 0.007), fat mass index (MC, − 1.6; 95% CI, − 2.6/− 0.5, p-value < 0.006) and body fat percentage (MC, − 8.1; 95% CI, − 12.0/− 4.2, p-value < 0.007) reduced in VD2 group as compared with VD1 and PL groups. Conclusion: The intake of 4000 IU/d vitamins D3 supplementation would elevate circulating 25(OH) D concentrations in nursing mothers with overweight or obesity and improve some indices of body composition. Trial registration: Iranian Registry of Clinical Trials (http://www.irct.ir: IRCT20140413017254N6) registered on 11-04-2018. Graphical Abstract: The graphical abstract of this clinical trial, is a figure that explains the final results of the manuscript in a clear and attractive way[Figure not available: see fulltext.] © 2022, The Author(s).
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