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First Case of New Delhi Metallo Β-Lactamase-1 (Ndm-1)-Producing Burkholderia Cepacia Complex in Iran Publisher



Adariani AR1 ; Sokhanvari S2 ; Nikbin VS3 ; Hosseinzadeh M1, 4 ; Khoram Z1 ; Solgi H1, 2
Authors
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Authors Affiliations
  1. 1. Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Genetics and Molecular Biology, School of Medicine Isfahan University of Medical Sciences, Isfahan, Iran

Source: Heliyon Published:2024


Abstract

The Burkholderia cepacia complex (Bcc) is a gram-negative bacillus, which is intrinsically resistant to several used antibiotics, and is now recognized as a group of opportunistic pathogens in Cystic Fibrosis patients. Here, for the first time, we report the case of a patient with New Delhi metallo β-lactamase (NDM)-positive Bcc lower respiratory tract infection in Iran. The patient was a 57-year-old male admitted to our hospital due to breathlessness, with a history of pulmonary thromboembolism and hypertension. On day 14, the patient underwent bronchoscopy and a bronchoalveolar lavage (BAL) specimen was taken. BAL culture grew Bcc. The drug resistance analysis showed positive NDM resistance, with susceptibility to only quinolones, therefore, levofloxacin was prescribed to the patient. He was discharged from the hospital on the 20th day, 4 days after the initiation of levofloxacin therapy, and died at home on the fifth day after discharge. This is the first report of a lung infection caused by an extensively drug-resistant NDM-positive Bcc strain in Iran. © 2024 The Authors
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