Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals Publisher



Kabiri N1 ; Asgary S2 ; Setorki M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran

Source: African Journal of Pharmacy and Pharmacology Published:2011


Abstract

Hypercholesterolemia, a high cholesterol diet and oxidative stress increase serum low density lipoprotein (LDL) levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals, thus providing protection to humans against contagious and degenerative diseases. The aim of this study was to assess the anti-fatty streak effects of concurrent hydroalcoholic extracts of Amaranthus caudatus L. (A. caudatus) and Hypericum perforatum L. (H. perforatum) as this were investigated in hypercholesterolemic rabbits and was compared with lovastatin. Rabbits were randomly divided into four groups which were fed with normal diet (control), high-cholesterol diet (hypercholesterolemic control group), high-cholesterol + concurrent hydroalcoholic extracts of A. caudatus (75 mg/kg daily) and H. perforatum (75 mg/kg daily) (treatment group), and high-cholesterol + lovastatin (10 mg/kg daily) (treatment group) for 60th days and then blood samples were obtained to measure plasma cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoproteinA (apoA), apolipoproteinB (apoB), malondialdehyde (MDA), C-reactive protein (CRP), Ox-LDL and AI aorta was also obtained for histological evaluation. The observation showed decrease in plasma cholesterol, TG, HDL, LDL, apoB, CRP, MDA, OX-LDL, AI and increased apoA and HDL between treatment groups and hypercholesterolemic control groups (P>0.05). The mean size of produced fatty streak also showed significant reduction in the treatment groupIII compared to the hypercholesterolemic group (P<0.05). This results showed that combination of hydroalcoholic extracts of A. caudatus and H. perforatum has anti-fatty streak effects in hypercholesterolemic rabbits. ©2011 Academic Journals.
Related Docs
View other Related Docs
1. Lipid Lowering by Hydroalcoholic Extracts of Amaranthus Caudatus L. Induces Regression of Rabbits Atherosclerotic Lesions, Lipids in Health and Disease (2011)
2. Effect of Hydroalcoholic Extract of Hypericum Perforatum on Selected Traditional and Novel Biochemical Factors of Cardiovascular Diseases and Atherosclerotic Lesions in Hypercholesterolemic Rabbits: A Comparison Between the Extract and Lovastatin, Journal of Pharmacy and Bioallied Sciences (2012)
3. Effects of Amaranthus Caudatus L. Extract and Lovastatin on Atherosclerosis in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2010)
4. Effects of Acute Verjuice Consumption With a High-Cholesterol Diet on Some Biochemical Risk Factors of Atherosclerosis in Rabbits, Medical Science Monitor (2010)
5. Hypolipidemic Activity of Allium Porrum L. in Cholesterol-Fed Rabbits, Journal of Medicinal Food (2006)
6. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
7. Effect of Artemisia Aucheri Extract on Atherogenic Lipids and Atherogenesis in Hypercholesterolemic Rabbits, Journal of Medicinal Plants (2007)
8. The Effects of Cornelian Cherry on Atherosclerosis and Atherogenic Factors in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2011)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (64)
Nizal Sarrafzadegan (13)
Other Related Docs
9. The Effect of Aloe Vera Leaf Gel on Fatty Streak Formation in Hypercholesterolemic Rabbits, Journal of Research in Medical Sciences (2012)
10. Hypocholesterolemic Effects of Purslane Extract on Serum Lipids in Rabbits Fed With High Cholesterol Levels, International Journal of Pharmacology (2007)
11. Pomegranate Peel Extract Supplementation Increases the Number of Endothelial Progenitor Cells and Attenuates the Development of Atherosclerosis Plaque, Journal of Isfahan Medical School (2012)
12. Impacts of Fresh Lime Juice and Peel on Atherosclerosis Progression in an Animal Model, ARYA Atherosclerosis (2013)
13. Antioxidant Activity in Some in Vitro Oxidative Systems of the Essential Oils From the Fruit and the Leaves of Platycladus Orientalis, Journal of Essential Oil Research (2011)
14. Evaluation of the Effects of Cucumis Sativus Seed Extract on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Journal of Food Science (2017)
15. The Protective Effects of Ginger on the Development of Coronary Atherosclerosis: An Experimental Animal Study, Der Pharmacia Lettre (2016)
16. Effects of Dietary Supplementation With Ghee, Hydrogenated Oil, or Olive Oil on Lipid Profile and Fatty Streak Formation in Rabbits, ARYA Atherosclerosis (2012)
17. Atherosclerosis and Statins, Journal of Isfahan Medical School (2011)
18. Effect of Artemisia Aucheri on Regression of Atherosclerotic Plaque in Rabbits, Journal of Medicinal Plants (2009)
19. Evaluation of the Effects of Vaccinium Arctostaphylos L. Fruit Extract on Serum Lipids and Hs-Crp Levels and Oxidative Stress in Adult Patients With Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2014)
20. Effect of Oat (Avena Sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-Density Lipoprotein Cholesterol (Hdl-C): An Updated Systematic Review, Current Problems in Cardiology (2023)
21. Hypocholesterolemic and Antiatherosclerotic Effect of Artemisia Aucheri in Hypercholesterolemic Rabbits, Pakistan Journal of Pharmaceutical Sciences (2010)
22. Impact of Sumac on Postprandial High-Fat Oxidative Stress, Pakistan Journal of Medical Sciences (2013)
23. Anti Atherosclerotic Effects of Verjuice on Hypocholesterolemic Rabbits, African Journal of Pharmacy and Pharmacology (2011)
24. Nigella Sativa L. Improves Lipid Profile and Prevents Atherosclerosis: Evidence From an Experimental Study on Hypercholesterolemic Rabbits, Journal of Functional Foods (2013)
25. Effect of Kelussia Odoratissima Mozaffarian on Lipid and Glucose Profile, Shiraz E Medical Journal (2015)
26. A Review of Plant‑Based Compounds and Medicinal Plants Effective on Atherosclerosis, Journal of Research in Medical Sciences (2017)
27. Dose Trifolium Pratense L. Protect Against Development of Fatty Streak in Coronary Arteries?, Journal of Medicinal Plants (2007)
28. Effects of Amirkabiria Odorastissima Mozaffarian on the Development and Progression of Fatty Streaks in Hypercholesterolemic Rabbits, Phytotherapy Research (2004)
29. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes, International Journal of Preventive Medicine (2014)
30. Anti-Hyperelipidemic Effects of Sumac (Rhus Coriaria L.): Can Sumac Strengthen Anti-Hyperlipidemic Effect of Statins?, Der Pharmacia Lettre (2016)
31. Effect of Gundelia Tournefortii L. on Some Cardiovascular Risk Factors in an Animal Model, Journal of HerbMed Pharmacology (2017)
32. Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum Pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats, Iranian Journal of Pharmaceutical Research (2009)
33. Effect of Glycyrrhiza Glabra Extract on Aorta Wall Atherosclerotic Lesion in Hypercholesterolemic Rabbits, Pakistan Journal of Nutrition (2007)
34. The Postprandial Effect of Apple Juice Intake on Some of the Biochemical Risk Factors of Atherosclerosis in Male Rabbit, Journal of Medicinal Plants Research (2009)
35. Effects of Alfalfa on Lipoproteins and Fatty Streak Formation in Hypercholesterolemic Rabbits, Pakistan Journal of Pharmaceutical Sciences (2008)
36. Effects of Dietary Red Clover on Blood Factors and Cardiovascular Fatty Streak Formation in Hypercholesterolemic Rabbits, Phytotherapy Research (2007)
37. Inhibitory Effect of Allium Cepa Extract on Ldl Oxidation Induced by Cuso 4 in Vitro Compared With Allium Sativum and Allium Ascalonicom, Iranian Journal of Pharmacology and Therapeutics (2011)
38. The Effect of Hydroalcoholic Extract of Dorema Aucheri on Cd40 Protein Expression in Thoracic Aorta of Male White Rabbits Fed With Hypercholesterolemic Diet, Journal of Isfahan Medical School (2012)
39. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
40. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
41. Anti-Atherosclerotic Effects of Aloe Vera in Hypercholesterolemic Rabbits, Journal of Babol University of Medical Sciences (2012)
42. Effects of Breads Containing Flaxseeds on Serum Levels of Apelin and Lipids in Hyperlipidemic Patients, Iranian Journal of Nutrition Sciences and Food Technology (2021)
43. Ldl Fatty Acids Composition As a Risk Biomarker of Cardiovascular Disease, Artery Research (2017)
44. Hypolipidemic Activity of Anethum Graveolens in Rats, Phytotherapy Research (2008)
45. The Effect of Ginger Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Clinical Trials, Phytomedicine (2018)
46. The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine, Molecules (2021)
47. Antidiabetic Effect of Hydroalcoholic Extract of Carthamus Tinctorius L. in Alloxan-Induced Diabetic Rats, Journal of Research in Medical Sciences (2012)
48. Protective Effect of Flavonoids Against Red Blood Cell Hemolysis by Free Radicals, Experimental and Clinical Cardiology (2005)
49. Rice Bran Oil Decreases Total and Ldl Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Hormone and Metabolic Research (2016)
50. A Placebo Control Double Blind Study of Effects of Atorvastatin + Allium Hirtifollium on Carotid Intima Media Thickness, Pakistan Journal of Medical Sciences (2013)