A Systematic Review With Meta-Analysis to Assess Alzheimer's Disease Biomarkers in Adults With or Without Obstructive Sleep Apnoea Publisher Pubmed



Mohammadi I¹ ; Adibparsa M² ; Najafi A¹ ; Sehat MS¹ ; Sadeghi M³ Show Affiliations
Source: International Orthodontics Published:2023

Abstract

Introduction: The aim was to design a meta-analysis evaluating the positron emission tomography (PET) uptake and cerebrospinal fluid (CSF), circulating levels of amyloid-β (Aβ), and tau proteins OSA group versus control group, as well as the association of these biomarkers with the severity of OSA. Material and methods: Four databases were searched until April 17, 2023, without any restrictions. The effect sizes were the standardized mean difference (SMD) along with a 95% confidence interval (CI). Results: A total of 21 articles were entered into the meta-analysis. The pooled SMDs of the CSF levels in OSA adults compared to controls were: –0.82 (P = 0.004) for Aβ42, –1.13 (P < 0.001) for Aβ40, 0.17 (P = 0.23) for p-tau, 0.04 (P = 0.65) for t-tau, 0.08 (P = 0.89) for Aβ42/Aβ40 ratio, and 0.81 (P = 0.001) for t-tau/Aβ42 ratio. The pooled SMD for the PET uptake of Aβ burden in OSA adults compared to controls was 0.30 (P = 0.03). The pooled SMDs of the circulating levels in OSA adults compared to controls were: 0.67 (P = 0.002) for Aβ42, 0.11 (P = 0.82) for Aβ40, 0.35 (P = 0.06) for p-tau, and 1.41(P = 0.005) for t-tau. The pooled SMDs for levels of Aβ42, Aβ40, total Aβ, p-tau, t-tau, and Aβ42/Aβ40 ratio in severe OSA adults compared to mild/moderate OSA adults were –0.15 (P = 0.33), 0.25 (P = 35), 0.04 (P = 87), –2.53 (P = 0.24), –0.24 (P = 0.52), and –0.28 (P = 0.30), respectively. Conclusions: The results indicated that CSF levels of Aβ42 and Aβ40 in OSA adults were significantly lower, but the CSF level of t-tau/Aβ42 ratio and PET Aβ burden uptake in OSA adults significantly were higher than in controls. © 2023 CEO