The Role of Soluble Fms-Like Tyrosine Kinase-1 Markers and Vascular Endothelial Growth Factor in Comparison With Color Doppler Sonography for Detecting Plasenta Accreta Publisher



Naghshineh E^{1, 2} ; Razaghi F^{1, 2} Show Affiliations
Source: Journal of Isfahan Medical School Published:2019

Abstract

Background: Regarding the relatively high prevalence of placenta accreta in pregnancy, and the lack of suitable methods for predicting this complication, this study aimed to determine the role of soluble fms-like tyrosine kinase-1 (SFLT-1) markers and vascular endothelial growth factor (VEGF) in comparison with color Doppler sonography in diagnosis of placenta accreta. Methods: In a cross-sectional study, 78 pregnant women who were referred to Alzahra and Shahid Beheshti hospitals in Isfahan, Iran, in 2017 and 2018 were studied. SFLT-1 and VEGF levels were measured, and embryo sonography was also performed. After surgery, the results of surgery were compared with the results of sonography, and the level of SFLT-1 and VEGF and the agreement of these markers with ultrasound were determined. Findings: There was no significant difference in mean VEGF level in terms of pregnancy outcomes (P = 0.90), but SFLT-1 level was significantly lower in Eckert group (P = 0.02). Meanwhile, SFLT-1/VEGT ratio was not different between the two groups (P = 0.66). Comparison of ultrasound findings and surgical results showed that surgical outcomes and ultrasonography were normal in 38 cases (48.7%). Moreover, in 16 cases (20.5%), the results of surgery and ultrasound showed the presence of plementa acrata. The agreement between ultrasonography and surgery was 0.36 (P < 0.001). Conclusion: According to the results of our study, the two markers SFLT-1 and VEGF, compared with ultrasound, were not suitable criteria for predicting placenta accreta. At the same time, according to the limitations of this study, further studies are suggested. © 2019, Isfahan University of Medical Sciences(IUMS). All rights reserved.