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Bioactivity-Guided Isolation of New Antiproliferative Compounds From Juniperus Foetidissima Willd Publisher Pubmed



Rafieiankopaei M1 ; Suleimani Dehkordi I2 ; Ghanadian M3, 4 ; Shokrollahi A2 ; Aghaei M3 ; Ayatollahi SA5 ; Choudhary MI6, 7
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, Shahrekord University of Medical Sciences, Shahrekord, Iran
  2. 2. Chemistry Department, Yasouj University, Yasouj, Iran
  3. 3. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Phytochemistry Research Center and School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
  7. 7. Faculty of Science, Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia

Source: Natural Product Research Published:2016


Abstract

Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines. © 2015 Taylor & Francis.
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