Bioactivity-Guided Isolation of New Antiproliferative Compounds From Juniperus Foetidissima Willd Publisher Pubmed

Summary: Research shows juniper compounds fight ovary and bladder cancer cells, suggesting new treatment possibilities. #CancerResearch #PlantMedicine

Rafieiankopaei M¹ ; Suleimani Dehkordi I² ; Ghanadian M^{3, 4} ; Shokrollahi A² ; Aghaei M³ ; Ayatollahi SA⁵ ; Choudhary MI^{6, 7}
Source: Natural Product Research Published:2016

Abstract

Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines. © 2015 Taylor & Francis.