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Rosmarinic Acid Prevents the Oxidation of Low Density Lipoprotein (Ldl) in Vitro Publisher



Ahmadvand H1 ; Khosrobeigi A2 ; Nemati L2 ; Boshtam M3 ; Jafari N3 ; Hosseini RH4 ; Pournia Y5
Authors
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Authors Affiliations
  1. 1. Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
  2. 2. Department of Biochemistry, Lorestan University of Medical Sciences, Khoramabad, Iran
  3. 3. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biology and Biochemistry, Payame Noor University, Tehran, Iran
  5. 5. Faculty of Medicine, Lorestan University of Medical Sciences, Iran

Source: Journal of Biological Sciences Published:2012


Abstract

The objective of the present study was to assess various antioxidative activities of Rosmarinic Acid (RA) and its effect on oxidation of Low Density Lipoprotein (LDL) induced by CuSO4 in vitro. It was demonstrated that RA was able to inhibit LDL oxidation and decrease the resistance of LDL against oxidation. Rosmarinic acid showed a decrease the formation of malondialdehyde (MDA) rate of 31.8, 36.7 and 50.3% at concentrations ranging from 100- 400 μM, respectively, against oxidation in vitro. The inhibitory effects of the RA on LDL oxidation were dose-dependent. Total antioxidant capacity of RA was 0.65±0.03 mmol of ascorbic acid equivalents/mmol RA. The RA showed remarkable scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC50 0.06±0.004 μM). This study showed that RA is a potent antioxidant and prevents the oxidation of LDL in vitro and it may be suitable for use in food and pharmaceutical applications. © 2012 Asian Network for Scientific Information.
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