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Cellular Automata Modeling of Hesperetin Release Phenomenon From Lipid Nanocarriers Publisher



Fathi M1 ; Mohebbi M2 ; Varshosaz J3 ; Shahidi F2
Authors
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Authors Affiliations
  1. 1. Department of Food Science and Technology, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Department of Food Science and Technology, Ferdowsi University of Mashhad, Mashhad, Iran
  3. 3. Department of Pharmaceutics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Food and Bioprocess Technology Published:2013


Abstract

Release behavior of encapsulated food bioactives is an important issue which has not been befittingly studied. Cellular automaton is a mathematical model that shows complex systems can be simulated based on interactions of their constructing components. In this research, cellular automata were proposed for simulating encapsulant release through lipid nanocarriers via diffusion mechanism in order to know effects of different parameters, e.g., encapsulant load, kind of neighborhood, probability of encapsulant solubility, encapsulant distribution, and type of release medium in two and three dimensions. The simulation results were validated using experimental hesperetin release data which showed good agreement indicating the ability of cellular automata to enhance the resolution over the complexity of the diffusion phenomenon during encapsulant release from nanocarriers. © 2012 Springer Science+Business Media New York.
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