Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of the Effect of Aspirin and Amantadine for the Treatment of Fatigue in Multiple Sclerosis: A Randomized, Blinded, Crossover Study Publisher Pubmed



Shaygannejad V1 ; Janghorbani M2 ; Ashtari F1 ; Zakeri H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Neurological Research Published:2012


Abstract

Objectives: The purpose of this study was to compare the relative efficacy of acetylsalicylic acid (ASA) and amantadine for the treatment of fatigue in multiple sclerosis (MS). Methods: A 10-week, randomized double-blind crossover clinical trial conducted from October 2009 to September 2010. Fifty-two patients with MS presenting fatigue at 21 to 53 years of age were randomly allocated to the two treatment groups. The first group received amantadine (100 mg twice daily) for a total of 4 weeks. The second group received ASA (500 mg once daily) for four weeks. After a 2-week washout period, they crossed over to the alternative treatment for 4 weeks. Patients were rated at baseline and the end of each phase with the Fatigue Severity Scale (FSS). Results: ASA appeared to be equivalent in efficacy and safety to amantadine. A significant decrease in FSS occurred in both groups. Of the 26 patients treated with amantadine, the mean (SD) of FSS decreased from 4.8 (1.4) to 4.0 (1.4) (P<0.001). In the 26 patients treated with ASA, the mean (SD) of FSS decreased from 4.6 (1.4) to 3.5 (1.5) (P<0.001). Discussion: This study demonstrates that both ASA and amantadine significantly reduce MS-related fatigue. Both ASA and amantadine have previously been shown to reduce fatigue, and we postulate that treatment with ASA and amantadine may have similar benefits. © W. S. Maney & Son Ltd 2012.
Related Docs
View other Related Docs
1. Does Amantadine Have Favourable Effects on Fatigue in Persian Patients Suffering From Multiple Sclerosis?, Neurologia i Neurochirurgia Polska (2009)
2. Multiple Sclerosis-Related Fatigue Lacks a Unified Definition: A Narrative Review, Journal of Research in Medical Sciences (2022)
3. Ginseng in the Treatment of Fatigue in Multiple Sclerosis: A Randomized, Placebo-Controlled, Double-Blind Pilot Study, International Journal of Neuroscience (2013)
4. Comparing the Effects of Reflexology and Relaxation on Fatigue in Women With Multiple Sclerosis, Iranian Journal of Nursing and Midwifery Research (2015)
5. Potential of Modified Mediterranean Diet to Improve Quality of Life and Fatigue Severity in Multiple Sclerosis Patients: A Single-Center Randomized Controlled Trial, International Journal of Food Properties (2020)
6. Association of Dietary Patterns With Systemic Inflammation, Quality of Life, Disease Severity, Relapse Rate, Severity of Fatigue and Anthropometric Measurements in Ms Patients, Nutritional Neuroscience (2020)
7. In Patients With Multiple Sclerosis, Both Objective and Subjective Sleep, Depression, Fatigue, and Paresthesia Improved After 3 Weeks of Regular Exercise, Frontiers in Psychiatry (2019)
8. Effects of Whole Body Vibration on Hormonal & Functional Indices in Patients With Multiple Sclerosis, Indian Journal of Medical Research (2015)
Experts (# of related papers)
View all Related Experts
Vahid Shaygannejad (64)
Masoud Etemadifar (39)
Other Related Docs
9. The Relation Between Vitamin D Status With Fatigue and Depressive Symptoms of Multiple Sclerosis, Journal of Research in Medical Sciences (2013)
10. Exercising Impacts on Fatigue, Depression, and Paresthesia in Female Patients With Multiple Sclerosis, Medicine and Science in Sports and Exercise (2016)
11. Seizure Characteristics in Multiple Sclerosis Patients, Journal of Research in Medical Sciences (2013)
12. Clinical Characteristics and Disability Progression of Early-And Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis, Journal of Clinical Medicine (2020)
13. Effects of Rivastigmine on Memory and Cognition in Multiple Sclerosis, Canadian Journal of Neurological Sciences (2008)
14. Compared to an Active Control Condition, in Persons With Multiple Sclerosis Two Different Types of Exercise Training Improved Sleep and Depression, But Not Fatigue, Paresthesia, and Intolerance of Uncertainty, Multiple Sclerosis and Related Disorders (2019)
15. Stability of Mental Toughness, Sleep Disturbances, and Physical Activity in Patients With Multiple Sclerosis (Ms)-A Longitudinal and Pilot Study, Frontiers in Psychiatry (2018)
16. Circadian Rhythm Sleep Disorders in Patients With Multiple Sclerosis and Its Association With Fatigue: A Case-Control Study, Journal of Research in Medical Sciences (2013)
17. Comparison of Prevalence Rates of Restless Legs Syndrome, Self-Assessed Risks of Obstructive Sleep Apnea, and Daytime Sleepiness Among Patients With Multiple Sclerosis (Ms), Clinically Isolated Syndrome (Cis) and Neuromyelitis Optica Spectrum Disorder (Nmosd), Sleep Medicine (2020)
18. Effect of Mediterranean Diet on Body Mass Index and Fatigue Severity in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2024)
19. Investigation of the Effects of Cocoa Powder on Fatigue Severity in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial, Clinical Nutrition Open Science (2024)
20. Effect of Aquatic Exercise Training on Fatigue and Health-Related Quality of Life in Patients With Multiple Sclerosis, Archives of Physical Medicine and Rehabilitation (2012)
21. Primary Progressive Multiple Sclerosis in Iran: A Consensus Recommendation for Diagnosis and Management, Multiple Sclerosis and Related Disorders (2018)
22. Sexual Dysfunction in Women With Neuromyelitis Optica Spectrum Disorders and Multiple Sclerosis, Sexuality and Disability (2022)
23. The Study of Circadian Rhythms Disorder and Its Relationship With Chronic Fatigue in Multiple Sclerosis in Compare With Control Group, Journal of Isfahan Medical School (2011)
24. Prescription Trends of Disease-Modifying Treatments for Multiple Sclerosis in Iran Over the Past 30 Years, Multiple Sclerosis and Related Disorders (2022)
25. Co-Supplementation of Synbiotics and Anti-Inflammatory-Antioxidant Rich Diet in Patients With Progressive Forms of Multiple Sclerosis: A Single-Center, Randomized Clinical Trial, Mediterranean Journal of Nutrition and Metabolism (2024)
26. Seizure in Iranian Patients With Multiple Sclerosis, Journal of Research in Medical Sciences (2013)
27. The Prevalence of Restless Legs Syndrome (Rls) in Patients With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis—An Update, Neurological Sciences (2023)
28. Th1, Th2 and Th17 Cytokine Profile in Patients With Multiple Sclerosis Following Treatment With Rapamycin, Iranian Journal of Immunology (2016)
29. The Effectiveness of Natalizumab Vs Fingolimod–A Comparison of International Registry Studies, Multiple Sclerosis and Related Disorders (2021)
30. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis, JAMA - Journal of the American Medical Association (2019)
31. Effect of Disease-Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years, Neurology (2021)
32. Prevalence of Cognitive Impairment (Ci) in Patients With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis, Caspian Journal of Internal Medicine (2024)
33. Prevalence of Multiple Sclerosis (Ms) in Iran: A Systematic Review and Meta-Analysis, Neurological Sciences (2022)
34. Safety and Efficacy of Fingolimod in Iranian Patients With Relapsing-Remitting Multiple Sclerosis: An Open-Label Study, Caspian Journal of Internal Medicine (2021)
35. Comparative Study of Quality of Life, Anxiety, Depression, and Fatigue Among Patients With Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis: The First Report From Iran, Multiple Sclerosis and Related Disorders (2018)
36. Late-Onset Multiple Sclerosis in Iran: A Report on Demographic and Disease Characteristics, Multiple Sclerosis and Related Disorders (2023)
37. The Effect of Ginger (Zingiber Officinale) Supplementation on Clinical, Biochemical, and Anthropometric Parameters in Patients With Multiple Sclerosis: A Double-Blind Randomized Controlled Trial, Food and Function (2023)
38. Interferon-Beta in Pediatric Multiple Sclerosis Patients: Safety in Short-Term Prescription, Acta Medica Iranica (2012)
39. Side Effects of Methylprednisolone Pulse Therapy in Treatment of Multiple Sclerosis, Journal of Isfahan Medical School (2012)
40. Effectiveness of Multiple Disease-Modifying Therapies in Relapsing-Remitting Multiple Sclerosis: Causal Inference to Emulate a Multiarm Randomised Trial, Journal of Neurology, Neurosurgery and Psychiatry (2023)
41. Islamic Fasting and Multiple Sclerosis, BMC Neurology (2014)
42. Multiple Sclerosis Severity Score (Msss) Improves the Accuracy of Individualized Prediction in Ms, Multiple Sclerosis Journal (2022)
43. Neutralizing Antibodies in Multiple Sclerosis Patients on Weekly Intramuscular Avonex and Biosimilar Interferon Beta-1A (Cinnovex): Comparing Results of Measurements in Two Different Laboratories, Journal of Immunological Methods (2013)
44. Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study, Clinical Neurology and Neurosurgery (2024)
45. Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis: A Registry-Based Study, Neurology (2024)
46. Assessment of Intelligence Quotient in Patients With Neuromyelitis Optica Spectrum Disease and Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2023)
47. Comparing Side Effects of Cinnovex With Avonex in Relapsing Remitting Multiple Sclerosis Patients, Journal of Isfahan Medical School (2009)
48. Clinical and Epidemiological Aspects of Multiple Sclerosis in Children, Iranian Journal of Child Neurology (2017)
49. Does Early-Onset Multiple Sclerosis Differ From Adult-Onset Form in Iranian People, Journal of Research in Medical Sciences (2010)
50. Patterns of Attention Deficit in Relapsing and Progressive Phenotypes of Multiple Sclerosis, Scientific Reports (2023)