The Relationship Between Retinal Layer Thickness and Cognition in Patients With Multiple Sclerosis: A Systematic Review of Current Literature Publisher



Moghadasi AN¹ ; Mirmosayyeb O^{2, 3} ; Ebrahimi N⁴ ; Sahraian MA¹ ; Mohammadi A⁵ ; Ghajarzadeh M^{1, 5} Show Affiliations
Source: Current Journal of Neurology Published:2023

Abstract

Background: This study was conducted to evaluate the relationship between retinal layer thickness (RLT) and cognition in patients with multiple sclerosis (MS). Methods: We searched PubMed, Scopus, Embase, Web of Science, and Google Scholar. The search strategy included the MeSH and text words as [“ora serrata” OR “retina” OR (“coherence tomography” AND “optical”) OR “OCT tomography” OR (tomography AND OCT) OR “optical coherence tomography” OR “OCT” OR “retinal thickness” OR “inner plexiform layer” OR “nerve fiber layer” OR “ganglion cell layer” OR “inner nuclear layer” OR “outer plexiform layer” OR “outer nuclear layer” OR “external limiting membrane” OR “inner segment layer” OR “outer segment layer” OR “retinal pigment epithelium”] AND [“cognition”* OR “cognitive function”* OR (function* AND cognitive)] AND [(sclerosis AND multiple) OR (sclerosis AND disseminated) OR disseminated sclerosis OR multiple sclerosis OR acute fulminating]. Results: The literature search revealed 1090 articles; after deleting duplicates, 980 remained. Finally, 14 studies were included. Totally, 1081 patients were evaluated. © 2023 Iranian Neurological Association, and Tehran University of Medical Sciences.