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The Effect of Nano-Curcumin Supplementation on Pentraxin 3 Gene Expression and Serum Level in Migraine Patients Publisher



Djalali M1 ; Djalali M1 ; Abdolahi M2 ; Mohammadi H3 ; Heidari H3 ; Hosseini S4 ; Sadeghizadeh M1
Authors
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Authors Affiliations
  1. 1. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Basic Sciences, Tehran Branch, Islamic Azad University, Tehran, Iran

Source: Reports of Biochemistry and Molecular Biology Published:2020


Abstract

Background: This study was designed to investigate the effect of nano-curcumin supplementation on pentraxin 3 (PTX3) gene expression and serum level in migraine patients. Methods: The present study, performed as a clinical trial, included 38 episodic migraine patients in two groups that received either nano-curcumin or placebo over a two-month period. At the start and the end of the study, PTX3 gene expression and serum levels were measured. Results: After two months of treatment, PTX3 gene expression and serum levels were both significantly less in the nano-curcumin than in the placebo group (P= 0.01 and P< 0.001, respectively). No significant gene expression differences were found between the two groups. Conclusions: Curcumin may have a potential inhibitory effect on PTX3 gene expression and serum levels in migraine disease and can be considered as an efficient therapy in migraine management. © 2020. Reports of Biochemistry and Molecular Biology.All Rights Reserved
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