The Review of in Vitro and in Vivo Studies Over the Glycyrrhizic Acid As Natural Remedy Option for Treatment of Allergic Asthma Publisher Pubmed



Fouladi S¹ ; Masjedi M¹ ; Hakemi MG¹ ; Eskandari N¹ Show Affiliations
Source: Iranian Journal of Allergy, Asthma and Immunology Published:2019

Abstract

Allergic asthma is the most common type of allergy which have become increasingly prevalent in all around the world. Airway eosinophilic inflammation is a major feature of allergic asthma. Glycyrrhiza uralensis (licorice) is one of the regular herbs in traditional Chinese medicine (TCM) as it has many effects on the immune system such as anti-inflammatory and immune regulatory activity; antiviral and antitumor effects. This review focuses on the licorice” components, mainly glycyrrhizic acid (GA) and derivatives structure that evaluate its effects on the allergic asthma. We performed searching articles in Pubmed, Web of Science, and Scopus data bank from 1990 to 2017. The search syntax were: glycyrrhizin OR glycyrrhizic acid OR glycyrrhizinic acid OR glycyrrhiza glabra OR liquorice root OR G. glabra OR glycyrrhizic Acid AND allergic asthma OR bronchial asthma OR asthma, bronchial OR airway hyperresponsiveness OR airway inflammation. Several molecular mechanisms and inflammatory mediators may possibly be responsible for efficacy of glycyrrhizin. Some in vitro studies indicated to the fact that possible mechanisms of anti-inflammatory effects could be through reduction of pro-inflammatory mediator's synthesis that motivates eosinophil, basophils and mast cells to release cytokines for the differentiation of T helper cells into Th2 cells to secrete interleukins. Furthermore, some transcription factors such as NF-κB, STAT6 and HDAC2 go between modulations of anti-asthmatic effects. The last but not the least it can be said that glycyrrhizin is potentially a good herbal drug with the lower most adverse effects for asthma treatment. Copyright© February 2019, Iran J Allergy Asthma Immunol. All rights reserved.