Effect of Preoperative Systemic Capsaicin on Tooth Sensitivity After In‑Office Bleaching:A Pilot Study Publisher



P Samimi POURAN ; M Kachuie MARZIE ; A Jafariandehkordi ABBAS ; Mm Shahtouri Maryam MONTAZERI ; M Khoroushi MARYAM
Source: Dental Research Journal Published:2024

Abstract

Background:Tooth bleaching sensitivity (TBS) after bleaching procedures is a common problem. This study was undertaken to determine the effect of preoperative systemic capsaicin on tooth sensitivity (TS) after in‑office bleaching procedures. Materials and Methods:Thirty participants received the treatment in this clinical trial.The subjects were randomly assigned to two groups (n = 15). Placebo and 0.25% capsaicin were administered three times daily for 24 h,with the first dose being administrated 1 h before the bleaching procedure. The subjects underwent two bleaching sessions at a 2‑week interval by applying 40% hydrogen peroxide gel on six upper anterior teeth.A visual analog scale (VAS) was used to evaluateTS.Data were analyzed with SPSS 24.Statistical analyses were carried out with theWilcoxon test and paired t‑test. Statistical significance was set at P ≤ 0.05. Results: In the capsaicin group, there was a significant increase in TBS between the immediate and 1‑h postoperative intervals and a significant decrease between 1‑ and 24‑h postoperative intervals (P = 0.01 and P = 0.000,respectively).In the placebo group,there was a significant decrease between immediate and 24‑h and between 1‑ and 24‑h postoperative intervals (P = 0.007, P = 0.02). MilderTS was detected in the placebo group 24 h after bleaching (P < 0.05). Conclusion: Under the limitations of this study, preoperative use of systemic capsaicin did not significantly affectTS after the in‑office bleaching procedure. © 2025 Elsevier B.V., All rights reserved.