Adrs Due to Covid-19 in Midterm Pregnancy: Successful Management With Plasma Transfusion and Corticosteroids Publisher Pubmed

Summary: Could convalescent plasma transfusions improve outcomes for pregnant women with COVID-19 ARDS? Research indicates they may help alongside corticosteroids. #COVID19 #Pregnancy

Soleimani Z^{1, 2} ; Soleimani A³
Source: Journal of Maternal-Fetal and Neonatal Medicine Published:2022

Abstract

Background: Management of acute respiratory distress syndrome (ARDS) in pregnant women infected with new severe acute respiratory syndrome Corona virus 2 (SARS-CoV2) is a challenging clinical task. Case: A 30- year-old woman (gravid 3, parity 2) presented at her 21 and 2/7 weeks gestation (pre pregnancy BMI: 36.1 kg/m2), with ARDS caused by SARS-CoV2 infection. She received lopinavir/ritonavir and azithromycin as well as early methyl prednisolone therapy. Given the persistent hypoxemia despite oxygen therapy via non rebreather face mask (FiO2:80%), convalescent plasma transfusion was administered that led to a mild clinical improvement as well as decrease in inflammatory markers. Growth of her fetus assessed by obstetric sonography was normal during hospital stay. Conclusion: Judicious corticosteroid therapy along with convalescent plasma transfusion to suppress viremia and cytokine storm can lead to favorable outcome in the pregnant women with ARDS caused by SARS-CoV2 infection without superimposed bacterial infection. © 2020 Informa UK Limited, trading as Taylor & Francis Group.