Isfahan University of Medical Sciences

Science Communicator Platform

Share By
Polymorphisms and Bipolar Disorder Publisher



Nikpour P ; Smedler E
Authors

Source: Handbook of the Biology and Pathology of Mental Disorders Published:2025


Abstract

Bipolar disorder is a severe mental disorder characterized by episodes of mania and depression. The heritability is estimated to be up to 80% in epidemiological studies. Parts of the variance is explained by common single nucleotide polymorphisms, and ongoing international consortia collect tens of thousands of patients to find the associated variants. So far, genome-wide association studies have found 64 significant loci with enrichment of genes involved in calcium signaling and synaptic structures. It is not known how these variants lead to disease, but studies are ongoing. One way to estimate the complete genetic risk is by calculating polygenic risk scores. Multiple studies have sought to unravel the polygenic architecture of bipolar disorder by associating various subphenotypes in bipolar patients with genetic risks for other disorders and traits. © 2025 Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. A Novel De Novo Frameshift Variant in the Chd2 Gene Related to Intellectual and Developmental Disability, Seizures and Speech Problems, Molecular Genetics and Genomic Medicine (2024)
2. Whole Exome Sequencing Revealed Variants in Four Genes Underlying X-Linked Intellectual Disability in Four Iranian Families: Novel Deleterious Variants and Clinical Features With the Review of Literature, BMC Medical Genomics (2023)
3. Using the Bayesian Variational Spike and Slab Model in a Genome-Wide Association Study for Finding Associated Loci With Bipolar Disorder, Annals of Human Genetics (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Amin Tabatabaiefar (4)
Mehrdad Zeinalian (1)
Other Related Docs
4. Cryab Missense Mutation Reveals Shared Pathogenesis of Familial Cardiomyopathy and Arrhythmia, Genes (2025)
5. X-Linked Mental Retardation-Hypotonic Facies Syndrome: Exome Sequencing Identifies Novel Clinical Characteristics Associated With C.5182G>C Mutation in the Atrx Gene, Molecular Genetics and Genomic Medicine (2022)
6. Genetic Variant Profiling of Neonatal Diabetes Mellitus in Iranian Patients: Unveiling 58 Distinct Variants in 14 Genes, Journal of Diabetes Investigation (2024)
7. Genetic Architecture Reconciles Linkage and Association Studies of Complex Traits, Nature Genetics (2024)
8. Germline Variants in Patients From the Iranian Hereditary Colorectal Cancer Registry, Cancer Cell International (2025)