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In Vitro Effect of Nicotine and Cotinine on the Susceptibility of Ldl Oxidation and Hemoglobin Glycosylation Publisher Pubmed



Asgary S1 ; Naderi GH2 ; Sarrafzadegan N3 ; Gharypur M2
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Isfahan Cardiovascular Research Ctr., Isfahan University Medical Science, Isfahan, P.O. Box 81465-1148, Iran
  2. 2. Department of Biochemistry, Isfahan Cardiovascular Research Ctr., Isfahan University Medical Science, Isfahan, P.O. Box 81465-1148, Iran
  3. 3. Department of Cardiology, Isfahan Cardiovascular Research Ctr., Isfahan University Medical Science, Isfahan, P.O. Box 81465-1148, Iran

Source: Molecular and Cellular Biochemistry Published:2003


Abstract

Nicotine, a major component of cigarette smoke, plays an important role in the development of cardiovascular disease and lung cancer in smokers. This study was designed to determine the in vitro effects of nicotine and its metabolite cotinine on the susceptibility of LDL to oxidation and hemoglobin glycosylation. Three different concentrations of each one (10, 15, 25 μg/ml) were used. Our data show that nicotine and cotinine are inhibitors for Cu2+-induced LDL oxidation but also they increase the glycosylation degree of hemoglobin. Nicotine at final concentration of (10, 15, 25 μg/ml) increases the rate of hemoglobin glycosylation 25, 32 and 47%, respectively, and cotinine at final concentrations increase the rate of glycosylation 8, 10 and 12%, respectively. Therefore promoting hemoglobin glycosylation is one of the alternations caused by smoking that increase risk of cardiovascular disease.
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