Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prevalence of Diabetic Neuropathy in Nonalcoholic Fatty Liver Disease (Nafld) Patients: A Systematic Review and Meta-Analysis Publisher



Rahmanian M1 ; Yaghoobpoor S1 ; Deravi N1 ; Poudineh M2 ; Mirmohammadali SN3 ; Kashanizadeh MG4 ; Poopak A5 ; Faridzadeh A6 ; Erabi G7 ; Amouei E8 ; Falahatian M9 ; Khani A10 ; Sadatmadani SF11 ; Noroozi M12 Show All Authors
Authors
  1. Rahmanian M1
  2. Yaghoobpoor S1
  3. Deravi N1
  4. Poudineh M2
  5. Mirmohammadali SN3
  6. Kashanizadeh MG4
  7. Poopak A5
  8. Faridzadeh A6
  9. Erabi G7
  10. Amouei E8
  11. Falahatian M9
  12. Khani A10
  13. Sadatmadani SF11
  14. Noroozi M12
  15. Firouzabadi FD13
Show Affiliations
Authors Affiliations
  1. 1. Student Research committee, school of Medicine, Shahid Beheshti University of medical sciences, Tehran, Iran
  2. 2. School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  3. 3. College of Health & Human Sciences, Kansas State University, Manhattan, KS, United States
  4. 4. Azad University of Medical Sciences, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology and Allergy & Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Student research committee, Urmia university of medical sciences, Urmia, Iran
  8. 8. Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Science, Tehran, Iran
  9. 9. Medical Radiation Sciences Research Group, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Department of Cardiovascular Disease, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  11. 11. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Department of biomedical engineering, university of Isfahan, Isfahan, Iran
  13. 13. Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States

Source: Neurology Asia Published:2024


Abstract

Nonalcoholic fatty liver disease (NAFLD) refers to the uncontrolled accumulation of triglyceride (TG) in the liver when the person has no other liver disease etiologies. Among all causes of neuropathy, diabetic neuropathy is the most common one worldwide, and it causes notable morbidity and increases mortality. The prevalence of diabetic neuropathy and NAFLD has been demonstrated in few studies. This study aims to summarize existing data estimating peripheral diabetic neuropathy prevalence among sonographically detected NAFLD patients. We searched PubMed, Scopus, Web of Science, and Google scholar for articles in the English language up until October 2021 for the clinical trials of diabetic neuropathy in NAFLD patients and used the articles for a systematic review and meta-analysis. Seven studies (6,918 patients with type 2 diabetes mellitus (T2DM)) were involved. The prevalence of diabetic neuropathy among T2DM patients with ultrasound (US) detected-NAFLD was 0.48 (95% CI= 0.31-0.65, I2= 99.01%), however it was not significantly different from patients without NAFLD (OR=1.02, 95% CI= 0.89-1.17. p=0.748, I2=81.6%). The prevalence of diabetic neuropathy among T2DM patients with NAFLD is not significantly different from patients without NAFLD. © 2024, ASEAN Neurological Association. All rights reserved.
Related Docs
View other Related Docs
1. Investigation of Cardiovascular Risk Factors in Diabetic and Nondiabetic Patients With Nonalcoholic Fatty Liver Disease, Journal of Research in Medical Sciences (2024)
2. First-Degree Relatives of Patients With Type 2 Diabetes Mellitus and Risk of Non-Alcoholic Fatty Liver Disease, Review of Diabetic Studies (2007)
3. Pre-Diabetes and Cardiovascular Risk Factors in Nafld Patients: A Retrospective Comparative Analysis, Frontiers in Endocrinology (2025)
4. Determination of Frequency of Diabetes and Pre-Diabetes in Patients With Nonalcoholic Fatty Liver Disease and Comparison With a Control Group, Journal of Isfahan Medical School (2016)
5. The Association of the Healthy Food Diversity Index With the Risk of Non-Alcoholic Fatty Liver Disease Among the Adult Population, Clinical Nutrition ESPEN (2024)
6. Association Between Dietary Glycemic Index and Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus, Frontiers in Endocrinology (2023)
7. Prevalence and Related Risk-Factors of Peripheral Neuropathy in Children With Insulin-Dependent Diabetes Mellitus, Journal of Research in Medical Sciences (2013)
8. Intake of Nutrients, Fiber, and Sugar in Patients With Nonalcoholic Fatty Liver Disease in Comparison to Healthy Individuals, International Journal of Preventive Medicine (2016)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (7)
Awat Feizi (7)
Other Related Docs
9. Adherence to Low Carbohydrate Diets and Non-Alcoholic Fatty Liver Disease: A Case Control Study, BMC Nutrition (2022)
10. Salsalate Efficacy on Treatment of Fatty Liver in Diabetes; Clinical Trial in Diabetic and Prediabetic Patients, Journal of Isfahan Medical School (2011)
11. Risk Score Model for Predicting Sonographic Non-Alcoholic Fatty Liver Disease in Children and Adolescents, Iranian Journal of Pediatrics (2011)
12. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
13. Prevalence of Nonalcoholic Fatty Liver Disease in Children With Renal Failure Underwent Treatment With Dialysis, International Journal of Preventive Medicine (2022)
14. The Effects of Intradermal Botulinum Toxin Type a Injections on Pain Symptoms of Patients With Diabetic Neuropathy, Journal of Research in Medical Sciences (2014)
15. Obesity and Air Pollution: Global Risk Factors for Pediatric Non-Alcoholic Fatty Liver Disease, Hepatitis Monthly (2011)
16. The Effects of Curcumin Supplementation on Liver Function, Metabolic Profile and Body Composition in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
17. Incidence of Metabolic Syndrome and Its Risk Factors Among Type 2 Diabetes Clinic Attenders in Isfahan, Iran, Endokrynologia Polska (2012)
18. Insulin-Like Growth Factor Binding Protein 3 Promoter Variant (Rs2854744) Is Associated With Nonalcoholic Fatty Liver Disease, Archives of Endocrinology and Metabolism (2023)
19. The Effects of Metformin Administration on Liver Enzymes and Body Composition in Non-Diabetic Patients With Non-Alcoholic Fatty Liver Disease And/Or Non-Alcoholic Steatohepatitis: An Up-To Date Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
20. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
21. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
22. Dietary Calcium Intake in Relation to Type-2 Diabetes and Hyperglycemia in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Scientific Reports (2022)
23. The Association of Dietary Phytochemical Index and Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
24. The Effect of a Mediterranean Diet on Metabolic Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
25. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
26. Hepatic Artery and Portal Vein Doppler Indexes in Non-Alcoholic Fatty Liver Disease Before and After Treatment to Prevent Unnecessary Health Care Costs, International Journal of Preventive Medicine (2014)
27. Treatment of Non-Alcoholic Fatty Liver Disease With Curcumin: A Randomized Placebo-Controlled Trial, Phytotherapy Research (2016)
28. The Influence of Diabetic Family History on the Development of Neuropathy in Type 2 Diabetes Patients: A Survival Analysis, Romanian Journal of Diabetes, Nutrition and Metabolic Diseases (2020)
29. The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study, Iranian Red Crescent Medical Journal (2017)
30. The Effect of Vitamin D Supplementation on Insulin Resistance in Patients With Nonalcoholic Fatty Liver, Journal of Isfahan Medical School (2015)
31. The Effect of Vitamin D Supplementation on Blood Sugar and Different Indices of Insulin Resistance in Patients With Non-Alcoholic Fatty Liver Disease (Nafld), Iranian Journal of Nursing and Midwifery Research (2016)
32. Effects of 12-Weeks Combined Trainings With Vitamin D Supplement on the Sensory-Motor Neuropathy in Women With Type 2 Diabetes, Journal of Isfahan Medical School (2015)
33. The Association Between Major Dietary Patterns With the Risk of Non-Alcoholic Fatty Liver Disease, Oxidative Stress and Metabolic Parameters: A Case–Control Study, Journal of Diabetes and Metabolic Disorders (2022)
34. Curcumin Supplementation Effect on Liver Enzymes in Patients With Nonalcoholic Fatty Liver Disease: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Nutrition reviews (2025)
35. Prognostic Role of Neutrophil to Lymphocyte Ratio in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis, Canadian Journal of Gastroenterology and Hepatology (2022)
36. Dietary Patterns and Risk of Non-Alcoholic Fatty Liver Disease, BMC Gastroenterology (2021)
37. Improving Data Adequacy of Ultrasonography Reports for Non-Alcoholic Fatty Liver Disease (Nafld) Through a National Structured Template, Acta Radiologica (2023)
38. Effect of Sodium–Glucose Cotransporter 2 Inhibitors on Insulin Resistance; a Systematic Review and Meta-Analysis, Acta Diabetologica (2023)
39. Carbohydrate Quality Index and Risk of Non-Alcoholic Fatty Liver Disease in Iranian Adults, BMC Endocrine Disorders (2024)
40. Effect of a Moderately Carbohydrate-Restricted Diet on Liver Enzymes, Steatosis and Fibrosis in Normal-Weight Individuals With Non-Alcoholic Fatty Liver Disease: Study Protocol for a Parallel Randomised Controlled Clinical Trial, BMJ Open (2023)
41. The Effect of Symbiotic Supplementation on Liver Enzymes, C‑Reactive Protein and Ultrasound Findings in Patients With Non‑Alcoholic Fatty Liver Disease: A Clinical Trial, International Journal of Preventive Medicine (2016)
42. Adaptation of Clinical Practice Guideline for Assessment of Liver Fibrosis in Patients With Non Alcoholic Fatty Liver Disease in Isfahan Province, International Journal of Preventive Medicine (2024)
43. Vitamin E + Ursodeoxycholic Acid (Udca) Versus Vitamin E for the Treatment of Non-Alcoholic Steatohepatitis (Nash), Journal of Isfahan Medical School (2010)
44. The Effects of Low Carbohydrate Diets on Liver Function Tests in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Research in Medical Sciences (2016)
45. Metabolic Syndrome in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors, Metabolic Syndrome and Related Disorders (2007)
46. Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents, Journal of Pediatric Gastroenterology and Nutrition (2017)
47. Doppler Perfusion Index in Adolescents With Nonalcoholic Fatty Liver Disease, Immunopathologia Persa (2021)
48. The Relationship Between Dietary Antioxidant Intake and Physical Activity Rate With Nonalcoholic Fatty Liver Disease (Nafld): A Case – Control Study, Clinical Nutrition ESPEN (2019)
49. Utility of Continuous Metabolic Syndrome Score in Assessing Risk of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Annals of Nutrition and Metabolism (2016)
50. Peripheral Neuropathy in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors, Acta Neurologica Scandinavica (2006)