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Effects of Treadmill Running on Extracellular Basal Levels of Glutamate and Gaba at Dentate Gyrus of Streptozotocin-Induced Diabetic Rats



Reisi P1 ; Alaei H1 ; Babri S2 ; Sharifi MR1 ; Mohaddes G3 ; Soleimannejad E4 ; Rashidi B5
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Physiology, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Department of Anatomy and Histology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2010

Abstract

BACKGROUND: The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats. METHODS: After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated. RESULTS: The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups. CONCLUSIONS: The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.
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