Adrenal Crisis-Induced Cardiogenic Shock (Accs): A Comprehensive Review Publisher Pubmed

Summary: Review highlights adrenal crisis-induced cardiogenic shock as a fatal AI presentation, stressing early glucocorticoid intervention. #AdrenalInsufficiency #CardiogenicShock

Heidarpour M¹ ; Shafie D² ; Eshraghi R³ ; Mirjalili SR⁴ ; Bahrami A³ ; Movahed MR^{5, 6}
Source: Heart Failure Reviews Published:2025

Abstract

Adrenal insufficiency (AI) is a disorder in which inadequate glucocorticoid and mineralocorticoid hormone production leads to a variety of symptoms, including fatigue, weight loss, and nausea. In some patients with unknown AI, adrenal crisis-induced cardiogenic shock (ACCS) can be the first presentation, resulting in a fatal situation. The ACCS may exhibit unresponsiveness to inotropes and fluid therapy; thus, glucocorticoid administration is the primary vital intervention, making early detection of AI essential. Hence, in this study, we review the case reports demonstrating acute cardiomyopathies in the context of AI. The review addresses the suggested underlying mechanisms, including the diminished protective effects of glucocorticoids against catecholamines in AI. We also highlighted some clues to aid physicians in considering AI as a differential diagnosis in critically ill patients presenting cardiogenic shock. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.