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The Epigenetic Overlap Between Obesity and Mood Disorders: A Systematic Review Publisher Pubmed



Gharipour M1 ; Barekatain M2 ; Sung J3 ; Emami N4 ; Sadeghian L5 ; Dianatkhah M6 ; Sarrafzadegan N7 ; Jahanfar S8
Authors
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Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Genetics and Epigenetics Department, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8158388994, Iran
  2. 2. Department of Psychiatry, School of Medicine and Behavioral Science Research Center, Isfahan University of Medical Science, Isfahan, 8174673461, Iran
  3. 3. Department Public Health Science, Genome & Health Big Data, Seoul National University, Seoul, 05649, South Korea
  4. 4. Research Department, Interventional Cardiology Research Center, Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8158388994, Iran
  5. 5. Research Department, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8158388994, Iran
  6. 6. Research Department, Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8158388994, Iran
  7. 7. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8158388994, Iran
  8. 8. MPH Program, School of Public Health, Central Michigan University, Mount Pleasant, 48859, MI, United States

Source: International Journal of Molecular Sciences Published:2020


Abstract

(1) Background: Obesity and mood disorders are considered as the most prevalent morbidities in many countries. We suppose that epigenetic mechanisms may induce higher rates of obesity in subjects who suffer from mood disorders. In this systematic review, we focused on the potential roles of DNA methylation on mood disorders and obesity development. (2) Methods: This systematic review was conducted in accordance with the PRISMA statement and registered in Prospero. A systematic search was conducted in MEDLINE, Scopus, Web of Science, Cochrane Central database, EMBASE, and CINHAL. We also conducted a Grey literature search, such as Google Scholar. (3) Results: After deduplication, we identified 198 potentially related citations. Finally, ten unique studies met our inclusion criteria. We have found three overlap genes that show significant DNA methylation changes, both in obesity and depression. Pathway analysis interaction for TAPBP, BDNF, and SORBS2 confirmed the relation of these genes in both obesity and mood disorders. (4) Conclusions: While mechanisms linking both obesity and mood disorders to epigenetic response are still unknown, we have already known chronic inflammation induces a novel epigenetic program. As the results of gene enrichment, pathways analysis showed that TAPBP, BDNF, and SORBS2 linked together by inflammatory pathways. Hypermethylation in these genes might play a crucial rule in the co-occurrence of obesity and mood disorders. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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