Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent

Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent

Mortezaee FT¹ ; Tabatabaiefar MA² ; Chaleshtori MH¹ ; Miraj S³

Show Affiliations

1. Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3. Deparmment of Obstetrics and Gynecology, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, P.O. Box: 88155/137, Iran

Source: Cell Journal Published:2014

Abstract

Uterine leiomyoma (UL) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. This study was carried out to investigate the association of ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (Ile462Val) polymorphisms with UL in female patients of Iranian origin. In this case-control study, 276 patients with UL and 156 healthy women were recruited. The genetic polymorphisms ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (Ile462Val) were genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). No significant difference were found in frequencies of both genotypes and alleles of ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (Ile462Val) polymorphisms between the two groups (p>0.05). Our findings indicated that these ESR1 and CYP1A1 polymorphisms were not associated with the development of UL in the cases reported here.

Related Docs

View other Related Docs

1. Polymorphisms of P53 Promoter and Susceptibility to Uterine Leiomyoma, Clinical and Experimental Obstetrics and Gynecology (2016)

2. Effect of Rs6983267 Polymorphism in the 8Q24 Region and Rs4444903 Polymorphism in Egf Gene on the Risk of Sporadic Colorectal Cancer in Iranian Population, Medical Oncology (2012)

3. Tp53 Pin3 Polymorphism Associated With Breast Cancer Risk in Iranian Women, Indian Journal of Cancer (2011)

4. Association of Tp53 Gene Codon 72 Polymorphism With Endometriosis Risk in Isfahan, International Journal of Reproductive BioMedicine (2013)

5. Screening Brca1 and Brca2 Mutation Frequencies in Breast Cancer Patients of West Iran Reveals a Novel Polymorphism in Brca1 Gene; [«L’Indagine Sulla Frequenza Di Mutazione Dei Brca1 E Brca2 in Pazienti Con Tumore Mammario Dell’Iran Occidentale Evidenzia Un Nuovo Polimorfismo Del Gene Brca1»], European Journal of Oncology (2015)

6. Eukaryotic Release Factor 3 and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)

7. Trinucleotide Repeat Polymorphism in Transforming Growth Factor Beta Receptor Type 1 Gene and Risk of Breast Cancer, Journal of Isfahan Medical School (2013)

8. Association of P53 (+16Ins-Arg) Haplotype With the Increased Susceptibility to Breast Cancer in Iranian-Azeri Women, Journal of Kerman University of Medical Sciences (2018)

Experts (# of related papers)

View all Related Experts

Simin Hemati (5)

Maryam Hajhashemi (2)

Style	Citing Format
MLA	Mortezaee FT, et al.. "Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent." Cell Journal, vol. 16, no. 2, 2014, pp. 225-230.
APA	Mortezaee FT, Tabatabaiefar MA, Chaleshtori MH, Miraj S (2014). Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent. Cell Journal, 16(2), 225-230.
Chicago	Mortezaee FT, Tabatabaiefar MA, Chaleshtori MH, Miraj S. "Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent." Cell Journal 16, no. 2 (2014): 225-230.
Harvard	Mortezaee FT et al. (2014) 'Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent', Cell Journal, 16(2), pp. 225-230.
Vancouver	Mortezaee FT, Tabatabaiefar MA, Chaleshtori MH, Miraj S. Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent. Cell Journal. 2014;16(2):225-230.
BibTex	@article{ author = {Mortezaee FT and Tabatabaiefar MA and Chaleshtori MH and Miraj S}, title = {Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent}, journal = {Cell Journal}, volume = {16}, number = {2}, pages = {225-230}, year = {2014} }
RIS	TY - JOUR AU - Mortezaee FT AU - Tabatabaiefar MA AU - Chaleshtori MH AU - Miraj S TI - Lack of Association Between Esr1 and Cyp1a1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent JO - Cell Journal VL - 16 IS - 2 SP - 225 EP - 230 PY - 2014 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract