Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Review on Toxic Epidermal Necrolysis-Like Superficial Wound Lesions: Issue and Challenge on 10 Clinical Entities Publisher Pubmed



Abtahinaeini B1 ; Pourmahdiboroujeni M2 ; Rastegarnasab F2 ; Emamjomeh A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Dermatology Division, Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Wound Journal Published:2024


Abstract

Toxic epidermal necrolysis (TEN) is a severe skin reaction caused by extensive epidermal and mucosal necrosis. This clinical phenomenon is known as an acute syndrome of apoptotic pan-epidermolysis (ASAP). The ASAP phenomenon is observed in conditions that mimic TEN, highlighting the challenge in distinguishing these conditions. While TEN is a well-recognized entity, distinguishing it from other TEN-like conditions presents significant diagnostic and treatment challenges. These conditions include drug rash with eosinophilia and systemic symptoms (DRESS), generalized bullous fixed drug eruption (GBFDE), acute generalized exanthematous pustulosis (AGEP), TEN-like methotrexate toxicity, mustard gas toxicity, pseudoporphyria, mycoplasma-induced rash and mucositis (MIRM), multisystem inflammatory syndrome in children (MIS-C), graft versus host disease (GVHD), and acute cutaneous lupus erythematosus and subacute cutaneous lupus erythematosus. This review explores these ten separate entities and debates their clinical features, pathophysiology, diagnosis and management. © 2024 The Author(s). International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Antiepileptic Medication-Induced Severe Cutaneous Adverse Reactions in Hospitalized Children: A Retrospective Study, Iranian Journal of Allergy, Asthma and Immunology (2024)
2. Cutaneous Manifestations and Considerations in Covid-19 Pandemic: A Systematic Review, Dermatologic Therapy (2020)
3. Covid-19 and Dermatological Manifestations, Atlas of Dermatology, Dermatopathology and Venereology: Cutaneous Infectious and Neoplastic Conditions and Procedural Dermatology (2021)
4. Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment, Iranian Journal of Pharmaceutical Research (2017)
5. Rapid Improvement of Genital Aphthae by Topical Fk-506 in Behcet's Disease, Journal of Isfahan Medical School (2011)
6. A Systematic Review on Mucocutaneous Manifestations of Covid-19 in Children, Iranian Journal of Dermatology (2022)
7. An Unusual Ten-Like Presentation of Juvenile Bullous Pemphigoid: A Diagnostic Challenge, Case Reports in Dermatological Medicine (2022)
8. Adverse Cutaneous Drug Reactions: Eight Year Assessment in Hospitalized Patients, Journal of Research in Medical Sciences (2014)
Experts (# of related papers)
View all Related Experts
Bahareh Abtahi Naeini (8)
Tooba Momen (3)
Other Related Docs
9. Prevalence of Skin Drug Eruptions in Dermatology Departments of Tehran Hospitals, Journal of Isfahan Medical School (2012)
10. Episcleritis; and Posterior Uveitis Misdiagnosed As Orbital Cellulitis in a Child Patient With Behcet’S Disease, SAGE Open Medical Case Reports (2023)
11. Covid-19 and Exacerbation of Dermatological Diseases: A Review of the Available Literature, Dermatologic Therapy (2021)
12. Clinical and Epidemiological Features of Patients With Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children From Adults, International Journal of Pediatrics (United Kingdom) (2022)
13. Autoimmune Versus Non-Autoimmune Cutaneous Features in Monogenic Patients With Inborn Errors of Immunity, Biology (2023)
14. Successful Treatment of Pemphigus Vulgaris With the Extensive Mucocutaneous Lesions in an Elderly Patient, Iranian Red Crescent Medical Journal (2014)
15. Evaluation of Severe Adverse Cutaneous Drug Reactions in Patients Admitted to Tertiary Care Center: A Cross-Sectional Study, Health Science Reports (2024)
16. Large Plaque Parapsoriasis in a Child: A Rare Entity in Pediatric Oncology, Indian Journal of Medical and Paediatric Oncology (2019)
17. Top 10 Acral Skin Manifestations Associated With Covid-19: A Scoping Review, Dermatologic Therapy (2021)
18. Mycosis Fungoides Presenting As Hypopigmented and Pigmented Purpuric Dermatosis-Like Lesions in a Girl: A Case Report and Literature Review, Iranian Journal of Dermatology (2022)