Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring

Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring Publisher

Summary: TLR-7 expression rises during UC flare-ups, indicating its potential as a non-invasive monitoring tool. Could it lead to better UC patient management? #IBD #Immunology

Asadzadehaghdaei H ; Rejali L ; Nourian M ; Chaleshi V ; Zamani N ; Ghavami S ; Nemati M ; Shahrokh S ; Norouzinia M ; Vosough M ; Nazemalhosseinimojarad E ; Zali M

Source: Advanced Biomedical Research Published:2023

Abstract

Background: Ulcerative colitis (UC) and Crohn's disease (CD) are two major types of inflammatory bowel diseases (IBDs). Toll-like receptors (TLRs) are expressed in the innate immune system compartments, in charge of identifying a wide range of microorganisms. The aim of the present study was to evaluate the expression of TLR-2, -7, and -8 in peripheral blood mononuclear cells (PBMC) of UC patients as a novel non-invasive primary inflammation sensor for monitoring the clinical course of UC candidates. Materials and Methods: In this cross-sectional study, total RNA was extracted from the PBMC of 42 UC patients along with 20 healthy donors. The mRNA levels of TLR-2, -7, and -8 were assessed using the quantitative real-time polymerase chain (qRT-PCR) reaction. Results: The present research study demonstrated no significant changes in TLR-2 mRNA expression in UC patients in comparison with the control group (P = 0.1264), whereas significant elevation (P = 0.0008) was distinguished in the TLR-7 expression of UC participants specifically during the remission course compared with healthy donors and flareup patients (P = 0.0004 and P = 0.0063, respectively). The last selected TLR, TLR-8 was not shown remarkable changes either between UC patients and the control group or between clinical courses of the disease. Conclusion: Here, among three nominated TLRs for predicting UC patients, TLR-7 was potentially selected according to the significant difference in mRNA expression in flareup UC patients and control donors. TLR-7 could be used as a novel non-invasive biomarker for monitoring UC patients in the active course of the disease. © 2023 Elsevier B.V., All rights reserved.

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Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring

Style	Citing Format
MLA	Asadzadehaghdaei H, et al.. "Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring." Advanced Biomedical Research, vol. 12, no. 1, 2023, pp. 54-.
APA	Asadzadehaghdaei H, Rejali L, Nourian M, Chaleshi V, Zamani N, Ghavami S, Nemati M, Shahrokh S, Norouzinia M, Vosough M, Nazemalhosseinimojarad E, Zali M (2023). Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring. Advanced Biomedical Research, 12(1), 54-.
Chicago	Asadzadehaghdaei H, Rejali L, Nourian M, Chaleshi V, Zamani N, Ghavami S, Nemati M, et al.. "Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring." Advanced Biomedical Research 12, no. 1 (2023): 54-.
Harvard	Asadzadehaghdaei H et al. (2023) 'Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring', Advanced Biomedical Research, 12(1), pp. 54-.
Vancouver	Asadzadehaghdaei H, Rejali L, Nourian M, Chaleshi V, Zamani N, Ghavami S, et al.. Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring. Advanced Biomedical Research. 2023;12(1):54-.
BibTex	@article{ author = {Asadzadehaghdaei H and Rejali L and Nourian M and Chaleshi V and Zamani N and Ghavami S and Nemati M and Shahrokh S and Norouzinia M and Vosough M and Nazemalhosseinimojarad E and Zali M}, title = {Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring}, journal = {Advanced Biomedical Research}, volume = {12}, number = {1}, pages = {54-}, year = {2023} }
RIS	TY - JOUR AU - Asadzadehaghdaei H AU - Rejali L AU - Nourian M AU - Chaleshi V AU - Zamani N AU - Ghavami S AU - Nemati M AU - Shahrokh S AU - Norouzinia M AU - Vosough M AU - Nazemalhosseinimojarad E AU - Zali M TI - Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring JO - Advanced Biomedical Research VL - 12 IS - 1 SP - 54 EP - PY - 2023 ER -

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