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Relaxant Effect of Essential Oil of Melissa Officinalis and Citral on Rat Ileum Contractions Publisher Pubmed



Sadraei H1 ; Ghannadi A2 ; Malekshahi K1, 2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Iran

Source: Fitoterapia Published:2003


Abstract

The relaxant effect of the essential oil of Melissa officinalis and its main component, citral, on rat isolated ileum contractions was evaluated. M. officinalis essential oil (MOEO) inhibited the response to KCl (80 mM), ACh (320 nM) and 5-HT (1.28 μM) in a concentration-dependent manner with a IC50 of approximately 20 ng/ml. Citral also had a concentration-dependent inhibitory effect on contraction of rat ileum with IC50s comparable to that of MOEO. © 2003 Elsevier Science B.V. All rights reserved.
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