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Anxiolytic Effects of Salvia Reuterana Boiss. on the Elevated Plus-Maze Model of Anxiety in Mice Publisher Pubmed



Rabbani M1 ; Sajjadi SE2 ; Jafarian A3 ; Vaseghi G1
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Source: Journal of Ethnopharmacology Published:2005


Abstract

The anxiolytic and sedative effects of hydroalcoholic extract (HE) of Salvia reuterana Boiss. was evaluated in mice. The HE of Salvia reuterana (100 mg/kg), increased the percentage of time-spent and the percentage of arm entries in the open arms of the elevated plus-maze. Spontaneous locomotor activity count measured in 15 min of the test was significantly decreased in animals pretreated with diazepam and 100 mg/kg of Salvia reuterana extract. Results of the present study provide support for the traditional usage of Salvia reuterana as a sedative and anxiolytic medicinal plant. © 2005 Elsevier Ireland Ltd. All rights reserved.
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