Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Impact of Low-Carbohydrate Diet on Serum Levels of Leptin and Adiponectin Levels: A Systematic Review and Meta-Analysis in Adult Publisher



Morshedzadeh N1 ; Ahmadi AR2 ; Tahmasebi R2 ; Tavasolian R3 ; Heshmati J4 ; Rahimlou M5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Varastegan Institute for Medical Sciences, Mashhad, Iran
  4. 4. Songhor Healthcare center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2022


Abstract

Background: Various studies have evaluated the effects of low-carbohydrate diet (LCD) on serum concentrations of adipokines. Although the association between LCD and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent. Objective: The purpose of this study was to systematically evaluate the effect of LCD on serum levels of leptin and adiponectin. Design: Electronic databases were retrieved in PubMed, Embase, Scopus and Web of Science to search relevant publications. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by the random-effect model. Cochrane Q test and I2 statistic were used to test heterogeneity. Subgroup analysis and meta-regression were applied to assess possible sources of heterogeneity. Results: A total of thirty-five articles were included in final analysis. Meta-analysis results revealed no statistical association between LCD and adiponectin concentration (WMD: 0.32 ng/ml, 95% CI: - 0.02, 0.66, p=0.062). Subgroup analysis showed that LCD increased adiponectin concentration in subjects under 45 years old and in studies with long term duration intervention. Also, did not observe a significant effect from the LCD on serum concentration of leptin (WMD: - 0.77 ng/ml, 95% CI: -3.15, 1.61, P=0.409). Subgroup analysis did not show any new information. The results of this study did not support the evidence for the positive effects of LCD on serum leptin and adiponectin levels. © 2021, Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis, Hormone and Metabolic Research (2020)
2. The Effect of Soy Products on Circulating Adiponectin and Leptin Concentration in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, International Journal of Clinical Practice (2021)
3. The Effect of Low Calorie Diet on Adiponectin Concentration: A Systematic Review and Meta-Analysis, Hormone and Metabolic Research (2015)
4. Comparison of the Effect of a Low-Carbohydrate Diet With a Low-Fat Diet on Anthropometric Indices and Body Fat Percentage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Nutrition and Food Security (2023)
5. Specific Dietary Patterns and Concentrations of Adiponectin, Journal of Research in Medical Sciences (2015)
6. The Influence of Fasting and Energy-Restricted Diets on Leptin and Adiponectin Levels in Humans: A Systematic Review and Meta-Analysis, Clinical Nutrition (2021)
7. Alpha-Lipoic Acid Effect on Leptin and Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, European Journal of Clinical Pharmacology (2020)
8. Effects of Dietary Patterns, Weight Loss Diets, and Dietary Components on Serum Adiponectin Levels, Journal of Isfahan Medical School (2012)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (15)
Nizal Sarrafzadegan (14)
Other Related Docs
9. Moderate Replacement of Carbohydrates by Dietary Fats Affects Features of Metabolic Syndrome: A Randomized Crossover Clinical Trial, Nutrition (2014)
10. Which Diets Are Effective in Reducing Cardiovascular and Cancer Risk in Women With Obesity? an Integrative Review, Nutrients (2021)
11. The Effect of Moderate Substitution of Dietary Carbohydrates by Fats on Serum Levels of Adipocytokines, Inflammatory Indices, and Biomarkers of Endothelial Function Amongwomen With Metabolic Syndrome, Journal of Zanjan University of Medical Sciences and Health Services (2012)
12. Effects of Coenzyme Q10 Supplementation on Serum Adiponectin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Drug Therapy (2020)
13. Dietary Acid Load Modifies the Effects of Apoa2–265 T > C Polymorphism on Lipid Profile and Serum Leptin and Ghrelin Levels Among Type 2 Diabetic Patients, BMC Endocrine Disorders (2022)
14. Adherence to the Low Carbohydrate Diet and the Risk of Breast Cancer in Iran, Nutrition Journal (2019)
15. The Effects of Silymarin Consumption on Inflammation and Oxidative Stress in Adults: A Systematic Review and Meta-Analysis, Inflammopharmacology (2024)
16. The Effects of Green Tea Extract Supplementation on Body Composition, Obesity-Related Hormones and Oxidative Stress Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomised Controlled Trials, British Journal of Nutrition (2024)
17. Impact of Melatonin Supplementation on Glycemic Parameters in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Current Pharmaceutical Design (2025)
18. Effect of Green Tea on Plasma Adiponectin Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Journal of the American College of Nutrition (2017)
19. Systematic Review and Meta-Analysis of Randomised, Controlled Trials on the Effects of Garlic Supplementation on Serum Adiponectin and Leptin Levels, International Journal of Clinical Practice (2021)
20. Beneficial Effects of L-Carnitine Supplementation for Weight Management in Overweight and Obese Adults: An Updated Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
21. Dietary Intakes and Leptin Concentrations, ARYA Atherosclerosis (2014)
22. Dietary Intake of Total, Animal, and Plant Proteins and Risk of All Cause, Cardiovascular, and Cancer Mortality: Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, The BMJ (2020)
23. Efficacy of L-Carnitine Supplementation for Management of Blood Lipids: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2019)
24. The Effect of Educational and Encouragement Interventions on Anthropometric Characteristics, Obestatin and Adiponectin Levels, ARYA Atherosclerosis (2019)
25. The Impact of a Low Glycemic Index Diet on Inflammatory Markers and Serum Adiponectin Concentration in Adolescent Overweight and Obese Girls: A Randomized Clinical Trial, Hormone and Metabolic Research (2016)
26. Can Flaxseed Supplementation Affect Circulating Adipokines in Adults? an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
27. Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Drug Targets (2023)
28. Is Coffee and Green Tea Consumption Related to Serum Levels of Adiponectin and Leptin?, International Journal of Preventive Medicine (2018)
29. Epidemiologic Evidence on Serum Adiponectin Level and Lipid Profile, International Journal of Preventive Medicine (2013)
30. Dietary Intake of Total, Animal and Plant Proteins and the Risk of Coronary Heart Disease and Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
31. Effects of Dietary Approaches to Stop Hypertension Diet Versus Usual Dietary Advice on Glycemic Indices in Women at Risk for Cardiovascular Disease; a Randomized Controlled Clinical Trial, Journal of Renal Injury Prevention (2017)
32. Bacterial Profile and Antimicrobial Resistance Patterns of Infected Diabetic Foot Ulcers in Iran: A Systematic Review and Meta-Analysis of Cross-Sectional Studies, International Journal of Lower Extremity Wounds (2022)
33. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
34. Phytosterol Supplementation Could Improve Atherogenic and Anti-Atherogenic Apolipoproteins: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Journal of the American College of Nutrition (2020)
35. Neck Circumference in Relation to Glycemic Parameters: A Systematic Review and Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2019)
36. Is Fatty Acid Composition of Breast Milk Different in Various Populations? a Systematic Review and Meta-Analysis, International Journal of Food Sciences and Nutrition (2020)
37. Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress, Nutrition and Health (2023)
38. Garlic Supplementation Reduces Circulating C-Reactive Protein, Tumor Necrosis Factor, and Interleukin-6 in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Nutrition (2019)
39. The Association of Dietary Carbohydrate Quality and Quantity With Obesity Among Iranian Adolescents: A Case-Control Study, BMC Pediatrics (2024)
40. The Effect of Green Coffee Extract Supplementation on Anthropometric Measures in Adults: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Medicine (2020)
41. Dash Diet, Insulin Resistance, and Serum Hs-Crp in Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial, Hormone and Metabolic Research (2015)
42. Anthropometric Indicators of Adiposity Related to Body Weight and Body Shape As Cardiometabolic Risk Predictors in British Young Adults: Superiority of Waist-To-Height Ratio, Journal of Obesity (2018)
43. Predictive Performance of Machine Learning Models for Kidney Complications Following Coronary Interventions: A Systematic Review and Meta-Analysis, International Urology and Nephrology (2025)
44. Predictive Role of Adiponectin and High-Sensitivity C-Reactive Protein for Prediction of Cardiovascular Event in an Iranian Cohort Study: The Isfahan Cohort Study, ARYA Atherosclerosis (2016)
45. Does Cocoa/Dark Chocolate Supplementation Have Favorable Effect on Body Weight, Body Mass Index and Waist Circumference? a Systematic Review, Meta-Analysis and Dose-Response of Randomized Clinical Trials, Critical Reviews in Food Science and Nutrition (2019)
46. The Relationship Between Dietary Patterns and Metabolic Phenotypes: A Cross-Sectional Study in a Representative Sample of Iranian Industrial Employees, Metabolic Syndrome and Related Disorders (2024)
47. Newborn Screening for Galactosaemia, Cochrane Database of Systematic Reviews (2020)
48. Association of Dietary Patterns With Serum Vitamin D Concentration Among Iranian Adults With Abdominal Obesity, Clinical Nutrition Open Science (2021)
49. Dietary Acid Load Adopts the Effect of Apob Ins/Del Genetic Variant (Rs11279109) on Obesity Trait, Cardiovascular Markers, Lipid Profile, and Serum Leptin Level Among Patients With Diabetes: A Cross-Sectional Study, Scientific Reports (2024)
50. Adherence to Lifelines Diet Score and Risk Factors of Metabolic Syndrome Among Overweight and Obese Adults: A Cross-Sectional Study, Frontiers in Nutrition (2022)