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Mxenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges Publisher Pubmed



Iravani S1 ; Varma RS2
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Regional Centre of Advanced Technologies and Materials, Palacky University in Olomouc, Slechtitelu 27, Olomouc, 783 71, Czech Republic

Source: ACS Biomaterials Science and Engineering Published:2021


Abstract

MXenes endowed with several attractive physicochemical attributes, namely, specific large surface area, significant electrical conductivity, magnetism, low toxicity, luminescence, and high biocompatibility, have been considered as promising candidates for cancer therapy and theranostics. These two-dimensional (2D) nanostructures endowed with photothermal, chemotherapeutic synergistic, and photodynamic effects have shown promising potential for decidedly effectual and noninvasive anticancer treatments. They have been explored for photothermal/chemo-photothermal therapy (PTT) and for targeted anticancer drug delivery. Remarkably, MXenes with their unique optical properties have been employed for bioimaging and biosensing, and their excellent light-to-heat transition competence renders them an ideal biocompatible and decidedly proficient nanoscaled agent for PTT appliances. However, several important challenging issues still linger regarding their stability in physiological environments, sustained/controlled release of drugs, and biodegradability that need to be addressed. This Perspective emphasizes the latest advancements of MXenes and MXene-based materials in the domain of targeted cancer therapy/diagnosis, with a focus on the current trends, important challenges, and future perspectives. © 2021 American Chemical Society.
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