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Efficacy of the Malva Sylvestris L. Flowers Aqueous Extract for Functional Constipation: A Placebo-Controlled Trial Publisher Pubmed



Elsagh M1 ; Fartookzadeh MR2 ; Kamalinejad M3 ; Anushiravani M4 ; Feizi A5 ; Behbahani FA1 ; Rafiei R6 ; Arjmandpour A6 ; Adibi P7
Authors
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Authors Affiliations
  1. 1. Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Ophthalmology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Gastroenterology, Faculty of Medicine, Islamic Azad University, Najafabad Branch, Najafabad, Iran
  7. 7. Gastroenterology Section, Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Complementary Therapies in Clinical Practice Published:2015


Abstract

Objective: To evaluate the efficacy of Malva sylvestris L. flowers extract for treatment of FC. Method: Adults with FC were allocated to receive the M.sylvestris L. flowers aqueous extract syrup (MSL, 1g extract/day) or placebo for four weeks. Frequency of constipation symptoms and stool forms were assessed every week. Self-reported improvement was assessed after treatment. Results: Compared with placebo, more increase was observed in defecation frequency (F=18.8, P<0.001) and more decrease was observed in frequency of all constipation symptoms by MSL (F=16.5 to 25.3, all P values <0.001). Also, the MSL group experienced more reduction in frequency of hard stool forms (45.4% vs. 9.1%, P<0.001) and reported more improvement in all symptoms (all P values <0.01) than placebo. Conclusion: The M.sylvestris L. flowers aqueous extract is efficacious and safe for the treatment of FC in adult patients. Investigating the mechanisms of action is warranted. IRCT2014031617032N1. © 2015 Elsevier Ltd.
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