Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Systematic Review and Meta-Analysis of Adverse Pregnancy Outcomes After Uterine Adenomyosis Publisher Pubmed



Razavi M1 ; Malekihajiagha A2 ; Sepidarkish M3 ; Rouholamin S4 ; Almasihashiani A5 ; Rezaeinejad M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pregnancy Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran
  4. 4. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran
  5. 5. Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran
  6. 6. Department of Obstetrics and Gynecology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Gynecology and Obstetrics Published:2019


Abstract

Background: Studies on the impact of adenomyosis and its pregnancy complications have yielded conflicting results. Objective: To determine the likelihood of adverse pregnancy outcomes among women with adenomyosis relative to women without adenomyosis. Search strategy: PubMed, Embase, Scopus, and Web of Science were searched for studies published up to June 15, 2018. Selection criteria: Observational studies with medically confirmed pregnancy outcomes as endpoints. Data collection and analysis: Two researchers independently screened and selected relevant studies. Dichotomous data for all adverse pregnancy outcomes were expressed as an odds ratio (OR) with 95% confidence interval (CI), and combined in a meta-analysis by using a random-effects model. Main results: Six studies (322 cases and 9420 controls) were eligible for inclusion in the meta-analysis. Women with adenomyosis had an increased likelihood of preterm birth (OR, 3.05; 95% CI, 2.08–4.47; P˂0.001), small for gestational age (OR, 3.22; 95% CI, 1.71–6.08; P˂0.001), and pre-eclampsia (OR, 4.35; 95% CI, 1.07–17.72; P=0.042). Conclusion: Adenomyosis seems to have a detrimental impact on pregnancy outcomes, resulting in a higher likelihood of preterm birth, small for gestational age, and pre-eclampsia. © 2019 International Federation of Gynecology and Obstetrics
Related Docs
1. The Protective Effect of Breastfeeding and Ingesting Human Breast Milk on Subsequent Risk of Endometriosis in Mother and Child: A Systematic Review and Meta-Analysis, Breastfeeding Medicine (2022)
2. Impact of Best-Fitted Control Selection on Effect Size: An Example in Functional Gi Disorder Case–Control Studies, International Journal of Environmental Research and Public Health (2021)
Experts (# of related papers)
View all Related Experts
Mitra Savabi (1)
Awat Feizi (1)