Investigating the Comparative Effect of Vitamin D Level With the Type of Complications in Henoch Schonlein Purpura and Kawasaki Disease; [Investigacion Del Efecto Comparativo Del Nivel De Vitamina D Con El Tipo De Complicaciones En La Purpura De Henoch-Schonlein Y La Enfermedad De Kawasaki] Publisher



Yeganeh MH¹ ; Sinaei R^{2, 3} ; Rouhi M⁴ ; Shiari R⁵ ; Parvaneh VJ⁴ ; Rahmani K⁶ ; Sheikhbahaei E⁷
Source: Reumatologia Clinica Published:2024

Abstract

Introduction and objectives: Henoch Schonlein purpura (HSP) and Kawasaki disease (KD) are two main inflammatory diseases among childhood vasculitis. Considering the anti-inflammatory effects of 25-hydroxyvitamin D3, we decided to investigate the association of serum 25-hydroxy vitamin D3 level with the type and severity of these conditions. Materials and methods: The present study was performed as a historical cohort of 254 affected children with KD and HSP vasculitis. The required data were extracted, using a researcher-made questionnaire from patients’ electronic file, and then they were analyzed after collecting information of the patients. Results: In HSP group, 54% of participants were boys. Similarly, in KD group, boys were more affected than girls. The comparative 25-hydroxyvitamin vitamin D3 level in HSP patients with and without renal involvement (P = 0.02), hematuria (P = 0.14), and in two groups with and without heart disease, and also with and without coronary artery dilatation in KD patients (P < 0.001) were significant. Discussion and conclusions: The findings showed that insufficient level of vitamin D3 were significantly associated with the exacerbation of complications of both diseases, and therefore it seems that vitamin D deficiency can be an effective predictive factor of severity in HSP and KD patients. © 2024