Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats Publisher



Dalayeli N1 ; Hajhashemi V2 ; Talebi A3 ; Minaiyan M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2024


Abstract

Background: Malnutrition and lack of micronutrients are seen in many patients with ulcerative colitis (UC). Considering that vitamins play an important role in preventing or protecting against inflammation at the metabolic, physiological, and pathological levels, this research was aimed to investigate the effect of a number of vitamin B groups in improving UC. Methods: Experimental colitis was induced by rectal administration of acetic acid (3%) in male Wistar rats, and mega doses of thiamine (20 mg/kg), riboflavin (15 mg/kg), pyridoxine (30 mg/kg), and cyanocobalamin (250 μg/kg) alone or in combination were administered intraperitoneally for 5 days. In another group, normal dose (1/10 of the above‑mentioned doses) of four vitamins in combination was administered for 15 days (started 10 days before colitis induction). Colon tissues were weighted and evaluated in terms of macroscopic, microscopic, and biochemical markers. Results: Normal dose of four vitamins in combination form and mega dose of thiamine caused a significant increase in the body weight of animals. All treatments except for pyridoxine (mega dose) diminished ulceration index, total colitis index, and colon weight compared to the control group. Myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels decreased significantly in all treatment groups. Conclusions: The anti‑inflammatory and anti‑ulcerative properties of selected B vitamins improved experimental colitis regardless of the dosage and duration of treatment. Despite its beneficial effect on biochemical markers, pyridoxine had the least effect in reducing the pathological features of colitis. More studies are needed to confirm the effect of these vitamins in the clinical setting of this disease. © 2024 International Journal of Preventive Medicine.
Related Docs
View other Related Docs
1. Salvia Officinalis Leaf Extracts Protect Against Acute Colitis in Rats, Research in Pharmaceutical Sciences (2022)
2. Assessment of Anemia in Patients With Various Types of Inflammatory Bowel Disease Under Medical Therapy, Journal of Isfahan Medical School (2018)
3. Evaluating Anti-Inflammatory Effect of Hydroalcoholic Extracts of Citrus Medica L. Pulp and Peel on Rat Model of Acute Colitis, Research Journal of Pharmacognosy (2023)
4. Ameliorative Effect of Galantamine on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2019)
5. Vitamin D Deficiency Associated With Disease Activity in Patients With Inflammatory Bowel Diseases, Digestive Diseases and Sciences (2015)
6. Effect of Tamarindus Indica L. Fruit Pulp and Seed Extracts on Experimental Ulcerative Colitis in Rats, Research in Pharmaceutical Sciences (2024)
7. Evaluation of Anti-Ulcerative Effect of Eryngium Billardieri Extracts on Experimental Colitis in Rats, Physiology and Pharmacology (Iran) (2024)
8. Anti-Inflammatory Effect of Myrtus Communis Hydroalcoholic Extract and Essential Oil on Acetic Acid-Induced Colitis in Rats, Journal of Reports in Pharmaceutical Sciences (2019)
Experts (# of related papers)
View all Related Experts
Mohsen Minaiyan (26)
Parvin Mahzouni (13)
Other Related Docs
9. Protective Effect of Apium Graveolens L. (Celery) Seeds Extracts and Luteolin on Acetic Acid-Induced Colitis in Rats, International Journal of Preventive Medicine (2021)
10. Vitamin D3 Induced Decrease in Il-17 and Malondialdehyde, and Increase in Il-10 and Total Antioxidant Capacity Levels in Patients With Irritable Bowel Syndrome, Iranian Journal of Immunology (2018)
11. Preventive Therapy of Experimental Colitis With Selected Iron Chelators and Anti-Oxidants, International Journal of Preventive Medicine (2012)
12. Effects of Vitamin D Supplementation on Serum 25‑Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta‑Analysis of Randomized Clinical Trials, International Journal of Preventive Medicine (2024)
13. Effects of Spirulina Supplementation in Patients With Ulcerative Colitis: A Double-Blind, Placebo-Controlled Randomized Trial, BMC Complementary Medicine and Therapies (2024)
14. Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome, Journal of the American College of Nutrition (2019)
15. Reactive Oxygen Metabolites and Anti-Oxidative Defenses in Aspirin-Induced Gastric Damage in Rats: Gastroprotection by Vitamin E, Pathophysiology (2006)
16. Protective Effects of Walnut Extract Against Oxidative Damage in Acetic Acid-Induced Experimental Colitis Rats, Physiology and Pharmacology (Iran) (2019)
17. Does Cisapride, As a 5Ht 4 Receptor Agonist, Aggravate the Severity of Tnbs-Induced Colitis in Rat?, Gastroenterology Research and Practice (2012)
18. The Association of Ultra-Processed Food Consumption With Adult Inflammatory Bowel Disease Risk: A Systematic Review and Dose-Response Meta-Analysis of 4 035 694 Participants, Nutrition Reviews (2024)
19. Colon Delivery of Budesonide Using Solid Dispersion in Dextran for the Treatment and Secondary Prevention of Ulcerative Colitis in Rat, International Journal of Preventive Medicine (2010)
20. Association Between Inflammatory Potential of the Diet and Ulcerative Colitis: A Case-Control Study, Frontiers in Nutrition (2021)
21. Anti-Inflammatory Effect of Apigenin and Hydroalcoholic Extract of Dracocephalum Kotschyi on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2017)
22. The Association Between Vitamin C Dietary Intake and Its Serum Levels With Anthropometric Indices: A Systematic Review and Meta-Analysis, Complementary Therapies in Clinical Practice (2023)
23. Anti-Inflammatory Effect of Prunus Armeniaca L. (Apricot) Extracts Ameliorates Tnbs-Induced Ulcerative Colitis in Rats, Research in Pharmaceutical Sciences (2014)
24. Efficacy of Low-Fat Milk and Yogurt Fortified With Vitamin D3 on Systemic Inflammation in Adults With Abdominal Obesity, Journal of Health, Population and Nutrition (2022)
25. The Effect of Laparoscopic Sleeve Gastrectomy on Serum Levels of Vitamin A, D and B12 and Iron Profile on Patients With Morbid Obesity, Advanced Biomedical Research (2023)
26. A Randomized Controlled Trial Investigating the Effect of a Diet Low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols on the Intestinal Microbiome and Inflammation in Patients With Ulcerative Colitis: Study Protocol for a Randomized Controlled Trial, Trials (2020)
27. The Effects of Vitamin D Supplementation on Inflammatory Biomarkers in Patients With Abnormal Glucose Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2021)
28. Review on Selected Potential Nutritional Intervention for Treatment and Prevention of Viral Infections: Possibility of Recommending These for Coronavirus 2019, International Journal of Food Properties (2020)
29. Is Dietary Vitamin B Intake Associated With Weight Disorders in Children and Adolescents? the Weight Disorders Survey of the Caspian-Iv Study, Health Promotion Perspectives (2019)
30. The Effect of Vitamin a and Vitamin C on Postoperative Adhesion Formation: A Rat Model Study, Journal of Research in Medical Sciences (2014)
31. The Association Between B Vitamins and the Risk of Covid-19, British Journal of Nutrition (2023)
32. The Effect of Thiamine and Vitamin C Combination on Mortality Rate of Patients With Severe Sepsis: A Randomized Control Clinical Trial Study, Journal of Isfahan Medical School (2022)
33. The Effects of Spirulina Supplementation on Serum Iron and Ferritin, Anemia Parameters, and Fecal Occult Blood in Adults With Ulcerative Colitis: A Randomized, Double-Blinded, Placebo-Controlled Trial, Clinical Nutrition ESPEN (2023)
34. Comparative Study of Berberis Vulgaris Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats, Iranian Journal of Pharmaceutical Research (2011)
35. Is It Time to Reconsider the Administration Of Thiamine Alone or in Combination With Vitamin C in Critically Ill Patients? a Meta-Analysis of Clinical Trial Studies, Journal of Intensive Care (2022)
36. The Association Between Dietary Total Antioxidant Capacity and Odds and Severity of Irritable Bowel Syndrome Among Iranian Adults: A Cross-Sectional Study, BMC Gastroenterology (2022)
37. The Effect of Combination Therapy With Hydrocortisone+ Ascorbic Acid+ Neurobion on the Prognosis of Multiple Trauma Patients; [تأثیر درمان ترکیبی با هیدروکورتیزون+آسکوربیک اسید+ نوروبیون در پیش آگهی بیماران مالتیپل تروما], Journal of Isfahan Medical School (2023)
38. Evaluating the Role of Biochanin a in Acetic Acid-Induced Colitis in Rats: Involvement of Nitric Oxide Pathway, Research Journal of Pharmacognosy (2024)
39. Validation and Optimization of Experimental Colitis Induction in Rats Using 2, 4, 6-Trinitrobenzene Sulfonic Acid, Research in Pharmaceutical Sciences (2012)
40. Anti-Inflammatory Effect of Curcuma Longa on Ulcerative Colitis Caused Via Acoh in Rats, Journal of Medicinal and Chemical Sciences (2023)
41. The Relationship Between Vitamin D, Clinical Outcomes and Mortality Rate in Icu Patients: A Prospective Observational Study, Journal of Research in Medical Sciences (2016)
42. Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-En-Y Gastric Bypass: A Double-Blind, Randomized Trial, Obesity Surgery (2024)
43. Protective Effect of Ginger Volatile Oil Against Acetic Acid-Induced Colitis in Rats: A Light Microscopic Evaluation, Journal of integrative medicine (2014)
44. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
45. Effect of Vitamin D Supplementation on C-Reactive Protein in Patients With Nonalcoholic Fatty Liver, International Journal of Preventive Medicine (2014)
46. A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases, Advances in Experimental Medicine and Biology (2021)
47. The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study, Immunity, Inflammation and Disease (2023)
48. The Association Between Dietary Patterns and the Risk of Developing Ulcerative Colitis, Clinical Nutrition ESPEN (2022)
49. Associations Between Dietary Intake of B Vitamins and Cardiovascular Risk Factors in Elderly Men: A Cross-Sectional Study, International Journal of Clinical Practice (2021)
50. The Effects of Spirulina (Arthrospira Platensis) Supplementation on Anthropometric Indices, Blood Pressure, Sleep Quality, Mental Health, Fatigue Status and Quality of Life in Patients With Ulcerative Colitis: A Randomised, Double-Blinded, Placebo-Controlled Trial, International Journal of Clinical Practice (2021)