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Multifunctional and Stimuli-Responsive Liposomes in Hepatocellular Carcinoma Diagnosis and Therapy Publisher

Summary: Review highlights liposomes as promising for liver cancer therapy, improving drug delivery and targeting with stimuli-responsive designs. #LiverCancer #Nanomedicine

Samaei SS1 ; Daryab M2 ; Gholami S3 ; Rezaee A4 ; Fatehi N5 ; Roshannia R6 ; Hashemi S7 ; Javani N8 ; Rahmanian P1 ; Amanibeni R9 ; Zandieh MA10 ; Nabavi N11 ; Rashidi M12, 13 ; Malgard N14 Show All Authors
Authors
  1. Samaei SS1
  2. Daryab M2
  3. Gholami S3
  4. Rezaee A4
  5. Fatehi N5
  6. Roshannia R6
  7. Hashemi S7
  8. Javani N8
  9. Rahmanian P1
  10. Amanibeni R9
  11. Zandieh MA10
  12. Nabavi N11
  13. Rashidi M12, 13
  14. Malgard N14
  15. Hashemi M15, 16
  16. Taheriazam A15, 17

Source: Translational Oncology Published:2024


Abstract

Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been widely applied in cancer therapy due to their biocompaitiblity, high drug loading and ease of synthesis and modification. The current review evaluates the application of liposomes for the HCC therapy. The drugs and genes lack targeting ability into tumor tissues and cells. Therefore, loading drugs or genes on liposomes can increase their accumulation in tumor site for HCC suppression. Moreover, the stimuli-responsive liposomes including pH-, redox- and light-sensitive liposomes are able to deliver drug into tumor microenvironment to improve therapeutic index. Since a number of receptors upregulate on HCC cells, the functionalization of liposomes with lactoferrin and peptides can promote the targeting ability towards HCC cells. Moreover, phototherapy can be induced by liposomes through loading phtoosensitizers to stimulate photothermal- and photodynamic-driven ablation of HCC cells. Overall, the findings are in line with the fact that liposomes are promising nanocarriers for the treatment of HCC. © 2024
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