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Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering Publisher Pubmed



Enayati MS1, 2 ; Behzad T1 ; Sajkiewicz P2 ; Rafienia M3 ; Bagheri R1 ; Ghasemimobarakeh L4 ; Kolbuk D2 ; Pahlevanneshan Z5 ; Bonakdar SH6
Authors
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Authors Affiliations
  1. 1. Department of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawinskiego 5B, Warsaw, 02-106, Poland
  3. 3. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department Textile Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  5. 5. Faculty of Chemistry, Isfahan University, Isfahan, Iran
  6. 6. National Cell Bank of Iran, Pasteur, Institute of Iran, Tehran, Iran

Source: Journal of Biomedical Materials Research - Part A Published:2018


Abstract

The article is focused on the role of nanohydroxy apatite (nHAp) and cellulose nanofibers (CNFs) as fillers in the electrospun poly (vinyl alcohol) (ES-PVA) nanofibers for bone tissue engineering (TE). Fibrous scaffolds of PVA, PVA/nHAp (10 wt.%), and PVA/nHAp(10 wt.%)/CNF(3 wt.%) were successfully fabricated and characterized. Tensile test on electrospun PVA/nHAp10 and PVA/nHAp10/CNF3 revealed a three-fold and seven-fold increase in modulus compared with pure ES-PVA (45.45 ± 4.77). Although, nanofiller loading slightly reduced the porosity percentage, all scaffolds had porosity higher than 70%. In addition, contact angle test proved the great hydrophilicity of scaffolds. The presence of fillers reduced in vitro biodegradation rate in PBS while accelerates biomineralization in simulated body fluid (SBF). Furthermore, cell viability, cell attachment, and functional activity of osteoblast MG-63 cells were studied on scaffolds showing higher cellular activity for scaffolds with nanofillers. Generally, the obtained results confirm that the 3-componemnt fibrous scaffold of PVA/nHAp/CNF has promising potential in hard TE. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1111–1120, 2018. © 2018 Wiley Periodicals, Inc.
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