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Impacts of Fcγriib and Fcγriiia Gene Polymorphisms on Systemic Lupus Erythematous Disease Activity Index Publisher Pubmed



Karimifar M1 ; Akbari K1 ; Arefnezhad R2 ; Fathi F3 ; Moosaeepour M4 ; Motedayyen H5
Authors
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Authors Affiliations
  1. 1. Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Autoimmune Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical Sciences, 5th Kilometer of Ravand Road, Kashan, Iran

Source: BMC Research Notes Published:2021


Abstract

Objective: Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have been identified as genetic factors in susceptibility to SLE. This study was aimed to investigate effects of two single nucleotide polymorphisms (SNPs) within FcγRIIB and FcγRIIIA genes on systemic lupus erythematous disease activity index (SLEDAI) in an Iranian population. Results: Our findings indicated TT and GG genotypes were the common genotypes of FcγRIIB and FcγRIIIA SNPs in SLE patients, respectively. There were no significant differences in genotype and allele frequencies of FcγRIIB and FcγRIIIA SNPs in SLE and healthy subjects. However, the frequencies of genotypes and alleles of FcγRIIB and FcγRIIIA SNPs were significantly associated with some clinical manifestations used to determine SLEDAI (P < 0.001–0.5). © 2021, The Author(s).
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