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Investigation of Different Targeting Decorations Effect on the Radiosensitizing Efficacy of Albumin-Stabilized Gold Nanoparticles for Breast Cancer Radiation Therapy Publisher Pubmed



Kefayat A1 ; Ghahremani F2 ; Motaghi H3 ; Mehrgardi MA3
Authors
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Authors Affiliations
  1. 1. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Department of Medical Physics and Radiotherapy, Arak University of Medical Sciences, Arak, 38481-76941, Iran
  3. 3. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran

Source: European Journal of Pharmaceutical Sciences Published:2019


Abstract

Gold nanoparticles (GNPs) radiosensitizing effect strongly depends on the tumor targeting efficacy. The aim of this study is to identify the most ideal targeting decoration for BSA-GNPs according to tumor targeting and biodistribution. Therefore, three well-known targeting agents (folic acid, glucose, and glutamine) were utilized for BSA-GNPs decoration. Glucose-BSA-GNPs, glutamine-BSA-GNPs, and folic acid-BSA-GNPs were synthesized and then, characterized by Fourier-transform infrared spectroscopy and UV-Spectrometry. Then, the GNPs were intravenously injected 10 mg/kg to 4T1 breast tumor-bearing mice to evaluate biodistribution and radiosensitizing effects. Folic acid and glutamine decorations could significantly increase tumor targeting efficacy of BSA-GNPs as 2.1 and 2.4 times increase of gold accumulation was detected in comparison with BSA-GNPs. They exhibited the highest radiosensitizing efficacy and caused about 33% decrease in tumors volume in comparison with BSA-GNPs after 6 Gy radiation therapy. All the GNPs were completely biocompatible. Although, glutamine-BSA-GNPs and folic acid-BSA-GNPs could significantly enhance the tumor targeting and radiosensitizing efficacy of BSA-GNPs, did not exhibit any significant advantage over each other. Therefore, glutamine and folic acid decoration of BSA-GNPs can significantly increase the tumor targeting and therapeutic efficacy as radiosensitizer. © 2019
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