Study of Lncrna Bancr Expression in Tumor Tissues and Adjacent Normal Tissues in Gastric Cancer Patients Publisher

Summary: Elevated BANCR lncRNA levels in gastric cancer suggest a role in tumor progression and potential as a biomarker, needing further research. Could this lead to better diagnostics? #GastricCancer #Biomarkers

Nikanfar R ; Dabbaghi R ; Rajabi A ; Hashemzadeh S ; Baradaran B ; Teimourian S ; Safaralizadeh R
Source: Advanced Biomedical Research Published:2023

Abstract

Background: Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various biological processes, including cancer development and progression. This study aimed to investigate the expression differences of the BRAF-activated non-coding RNA (BANCR) gene in GC tissues compared to adjacent normal tissues. The potential diagnostic significance of BANCR in GC was explored, with the aim of improving diagnostic and therapeutic approaches for this global health burden. Materials and Methods: Tissue samples from 100 gastric cancer (GC) patients were collected, and BANCR expression was analyzed using quantitative real-time PCR. Correlations between BANCR expression and clinicopathological features were assessed, and its biomarker potential was evaluated. Results: In individuals diagnosed with GC, the expression of BANCR was notably elevated in tumor tissues compared to adjacent normal tissues (P < 0.0001). However, the analysis of gene expression data did not demonstrate any statistically significant correlation between elevated BANCR expression and clinicopathological features. According to the ROC analysis, BANCR demonstrated an AUC of 0.6733 (P < 0.0001), with a sensitivity of 73% and a specificity of 45%. However, further evaluation is required to determine its potential as a biomarker (CI 95% = 0.5992 to 0.7473). Conclusions: The observed upregulation of BANCR in GC tissues implies its potential involvement as an oncogenic lncRNA in GC patients. Furthermore, BANCR may serve as a promising biomarker for identification and treatment of GC. © 2023 Elsevier B.V., All rights reserved.