Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prevalence and Some Related Factors of Low Muscle Mass in Older Adults: Findings From the Tehran Lipid and Glucose Study Publisher



Abiri B1 ; Ahmadi AR2 ; Nikoohemmat M1 ; Valizadeh A1, 3 ; Mahdavi M1 ; Valizadeh M1 ; Momenan A4 ; Haidari F5 ; Azizi F6 ; Hosseinpanah F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 19395-476, Number 24, Yemen Street, Shahid Chamran Highway, Tehran, Iran
  2. 2. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Industrial Engineering, Iran University of Science and Technology, Tehran, Iran
  4. 4. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. School of Health, Medical and Applied Sciences, CQUniversity, Brisbane, Australia
  6. 6. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2024


Abstract

Objectives: The global population is undergoing rapid aging, and the consequential decline in skeletal muscle mass with age presents substantial health risks, underscoring the importance of precise identification and gender-specific measurements. This study aimed to investigate the prevalence of low muscle mass among individuals aged > 60 years and identifying potential risk factors. Methods: This study, conducted within the framework of Phase VII of the Tehran Lipid and Glucose Study (TLGS), included 860 participants selected through meticulous inclusion and exclusion criteria, focusing on good health. Various demographic, anthropometric, and metabolic measurements were collected, and bioelectrical impedance analysis (BIA) was employed for skeletal muscle mass assessment. Multiple logistic regression analysis was conducted to evaluate associations between low muscle mass and various factors. Results: The prevalence of low skeletal muscle mass was 16.4% (CI: 14.06–19.03), with gender-based variations (20.24% (CI: 16.66–24.36) in males vs. 12.73% (CI: 9.92–16.19) in females). Multiple logistic regression analysis revealed associations between low muscle mass and increasing age, male gender, smoking, low physical activity, and higher HDL levels (P < 0.05). Protective effects were observed with higher BMI, weight, height, waist and hip circumference, and serum triglyceride levels (P < 0.05). Conclusion: This study provides valuable insights into the prevalence and related factors of low skeletal muscle mass among older adults. Addressing modifiable risk factors and promoting healthy lifestyle behaviors are crucial steps in preventing and managing sarcopenia. Further longitudinal research is recommended to explore causal pathways and inform targeted interventions for optimizing muscle health across the lifespan. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024.
Related Docs
View other Related Docs
1. Association Between Metabolic Phenotypes and Incident Pre-Sarcopenia: 3 Years Follow-Up of Tehran Lipid and Glucose Study, BMC Public Health (2024)
2. Sarcopenia and Its Determinants Among Iranian Elderly (Sarir): Study Protocol, Journal of Diabetes and Metabolic Disorders (2012)
3. Sarcopenia and Its Associated Factors in Iranian Older Individuals: Results of Sarir Study, Archives of Gerontology and Geriatrics (2016)
4. Dietary Calcium Intake and Risk of Obesity in School Girls Aged 8-10 Years, Journal of Research in Medical Sciences (2012)
5. Predictors of Metabolic Syndrome in the Iranian Population: Waist Circumference, Body Mass Index, or Waist to Hip Ratio?, Cholesterol (2013)
6. Dietary and Non-Dietary Determinants of Central Adiposity Among Tehrani Women, Public Health Nutrition (2008)
7. Association Between Serum Uric Acid Level and Metabolic Syndrome Components, Journal of Diabetes and Metabolic Disorders (2015)
8. The Association Between Glycemic Index, Glycemic Load and Total Carbohydrate Intake and Risk of Premature Coronary Artery Disease: Iran Premature Coronary Artery Disease Study (Ipad) - a Case-Control Study, Nutrition, Metabolism and Cardiovascular Diseases (2024)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (12)
Masoumeh Sadeghi (9)
Other Related Docs
9. Association of the Elderly Dietary Index With Cardiovascular Disease Risk Factors in Elderly Men: A Cross-Sectional Study, Nutrition and Dietetics (2019)
10. Association Between Body Composition Indices and Vascular Health: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2025)
11. Association of Glycaemic Index and Glycaemic Load With Metabolic Syndrome in an Iranian Adult Population: Isfahan Healthy Heart Program, Nutrition and Dietetics (2017)
12. A Meta-Analysis of the Effect of Probiotic Administration on Age-Related Sarcopenia, Food Science and Nutrition (2023)
13. Serum Klotho Levels in Trained Athletes, Nephro-Urology Monthly (2016)
14. Prognostic Value of Grip Strength: Findings From the Prospective Urban Rural Epidemiology (Pure) Study, The Lancet (2015)
15. Patterns of Nutrient Intake in Relation to Sarcopenia and Its Components, Frontiers in Nutrition (2021)
16. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
17. Evaluation of Heart Rate Reserve and Exercise Capacity in Individuals With and Without Metabolic Syndrome in Isfahan, Iranian Heart Journal (2012)
18. Elastic Band Resistance Training Increases Adropin and Ameliorates Some Cardiometabolic Risk Factors in Elderly Women: A Quasi-Experimental Study, BMC Sports Science, Medicine and Rehabilitation (2022)
19. Assessing Body Shape Index As a Risk Predictor for Cardiovascular Diseases and Metabolic Syndrome Among Iranian Adults, Nutrition (2014)
20. First Report on Path Analysis for Cardiometabolic Components in a Nationally Representative Sample of Pediatric Population in the Middle East and North Africa (Mena): The Caspian-Iii Study, Annals of Nutrition and Metabolism (2013)
21. An Updated Systematic Review on the Effects of Aerobic Exercise on Human Blood Lipid Profile, Current Problems in Cardiology (2023)
22. Association Between Dietary Inflammatory Index and Phase Angle in University Employees: A Cross-Sectional Study, Scientific Reports (2024)
23. Effects of Vitamin D on Insulin Resistance in Nursing Home Residents: An Interventional Study, Endokrynologia Polska (2012)
24. Validity and Reliability of Persian Version of Low Physical Activity Questionnaire (Lopaq), BMC Nephrology (2024)
25. Relationship Between Metabolic Diseases (Diabetes and Hyperlipidemia) With Depression in the Elderly, Journal of Isfahan Medical School (2022)
26. Sleep Duration and Sarcopenia Risk: A Systematic Review and Dose-Response Meta-Analysis, Sleep and Breathing (2020)
27. Association of a Body Shape Index and Hip Index With Cardiometabolic Risk Factors in Children and Adolescents: The Caspian-V Study, Journal of Diabetes and Metabolic Disorders (2021)
28. The Relation of Cardiovascular Risk Factors and Electrocardiographic Change; Isfahan Healthy Heart Program, Journal of Isfahan Medical School (2010)
29. Evaluation of Heart Rate Reserve and High-Sensitivity C-Reactive Protein in Individuals With and Without Metabolic Syndrome in Isfahan, Iran, ARYA Atherosclerosis (2012)
30. Dietary Insulin Index and Load and Cardiometabolic Risk Factors Among People With Obesity: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
31. Association of Circulating C-Reactive Protein and High-Sensitivity C-Reactive Protein With Components of Sarcopenia: A Systematic Review and Meta-Analysis of Observational Studies, Experimental Gerontology (2021)
32. Metabolic Syndrome in Iranian Elderly, ARYA Atherosclerosis (2012)
33. Associations Between Dietary Total Antioxidant Capacity and Sarcopenia: A Cross-Sectional Study, Nutrition Journal (2024)
34. Dietary Energy Density, Metabolic Parameters, and Blood Pressure in a Sample of Adults With Obesity, BMC Endocrine Disorders (2023)
35. The Relationship Between Food-Based Pro-Inflammatory Diet and Sarcopenia: Findings From a Cross-Sectional Study in Iranian Elderly People, Frontiers in Medicine (2021)
36. The First Cut-Off Points for Generalized and Abdominal Obesity in Predicting Lipid Disorders in a Nationally Representative Population in the Middle East: The National Survey of Risk Factors for Non-Communicable Diseases of Iran, Archives of Medical Science (2009)
37. Cardiovascular Disease Risk Factors, Metabolic Syndrome and Obesity in an Iranian Population, Eastern Mediterranean Health Journal (2008)
38. The Association of Dietary Energy Density and Body Composition Components in a Sample of Iranian Adults, Frontiers in Nutrition (2021)
39. Comparison of the Prevalence of Metabolic Syndrome in Military and Non-Military (Civilian) Personnel and Its Relationship With Lifestyle, Journal of Military Medicine (2021)
40. Gender Differences in Risk Factors and Outcomes After Cardiac Rehabilitation, Acta Cardiologica (2008)
41. Cardiometabolic Risk Factors and Framingham Risk Score in Severely Obese Patients: Baseline Data From Dietbra Trial, Nutrition, Metabolism and Cardiovascular Diseases (2020)
42. The Cut-Off Values of Anthropometric Indices for Identifying Subjects at Risk for Metabolic Syndrome in Iranian Elderly Men, Journal of Obesity (2014)
43. Relationship Between Physical Activity Level and Muscle Markers in a Population-Based Sample of Children and Adolescents, Asian Journal of Sports Medicine (2021)
44. Determinants of Changes in Metabolic Syndrome Components in a 12-Year Cohort of Iranian Adults, Metabolic Syndrome and Related Disorders (2019)
45. All-Age Relationship Between Arm Span and Height in Different Ethnic Groups, European Respiratory Journal (2014)
46. The Effect of Physical Activity on Mortality and Cardiovascular Disease in 130 000 People From 17 High-Income, Middle-Income, and Low-Income Countries: The Pure Study, The Lancet (2017)
47. Healthy Eating Index and Cardiovascular Risk Factors Among Iranian Elderly Individuals, ARYA Atherosclerosis (2017)
48. Lipid Accumulation Product and Visceral Adiposity Index for Incidence of Cardiovascular Diseases and Mortality; Results From 13 Years Follow-Up in Isfahan Cohort Study, Obesity Science and Practice (2024)
49. Body Mass Index, Waist-Circumference and Cardiovascular Disease Risk Factors in Iranian Adults: Isfahan Healthy Heart Program, Journal of Health, Population and Nutrition (2013)
50. The Association Between Dietary Acid Load and Body Composition in Physical Education Students Aged 18–25 Years, Journal of Health, Population and Nutrition (2022)