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Massive Splenomegaly: A Rare Presentation of Megaloblastic Anemia Publisher



Gholipurshahraki T1 ; Sadeghi A2 ; Oghab P3 ; Farrokhi P1 ; Moghaddas A1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Oncology and Hematology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2021


Abstract

Megaloblastic anemia is a common disorder with various manifestations. Of the many causes, cobalamin or folate deficiency can eventuate into megaloblastic anemia. It can lead to pancytopenia and mild to moderate splenomegaly, but massive splenomegaly rarely seen in this situation. We describe a 39-year-old woman with marked enlargement of the spleen and pancytopenia that was found to have megaloblastic anemia. The splenomegaly and blood count resolved 4 months after initiation of vitamin B12 therapy. It is important to know massive splenomegaly may occur in megaloblastic anemia, and although it is rare, bur can reversible with early treatment. © 2021 Tehran University of Medical Sciences.