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Preparation and Characterization of Micelles of Oligomeric Chitosan Linked to All-Trans Retinoic Acid Publisher



Fattahi A1, 2 ; Golozar MA1 ; Varshosaz J2, 3 ; Sadeghi HM4 ; Fathi M1
Authors
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Authors Affiliations
  1. 1. Biomaterials Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84146-83111, Iran
  2. 2. Isfahan Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan 81745-359, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Biotechnology Department, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Carbohydrate Polymers Published:2012


Abstract

New amphiphilic chitosan derivatives of all trans retinoic acid-chitosan (RA-chitosan) with different molar feeding ratios of all trans retinoic acid (ATRA) were synthesized. The degree of ATRA substitution ranged from 8.72% to 18.78%. The RA-chitosan formed micelles with an average size of 142.14-208.4 nm, and zeta potential of +27.25 to 34.48 mV. The critical association concentration (CAC) was found to range from 1.3 × 10-2 to 2.13 × 10-2 mg ml-1. Upon evaluation, the RA-chitosan shows no significant cytotoxicity on Hela and HepG2 cells. Analysis of micelles loaded with ATRA revealed that the size of micelles decreased by increasing loaded drug content while zeta potential did not change. ATRA was released slowly over 3-day period, and drug content had no effect on the release rate. These phenomena make RA-chitosan micelles as a candidate for drug carrier. © 2011 Elsevier Ltd. All rights reserved.
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