Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Improving the Solubility and in Vitro Cytotoxicity (Anticancer Activity) of Ferulic Acid by Loading It Into Cyclodextrin Nanosponges Publisher Pubmed



Rezaei A1, 2 ; Varshosaz J3 ; Fesharaki M4 ; Farhang A2 ; Jafari SM5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Cell Science, Research Center Medical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
  6. 6. Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Pardis, Basidj Square, Gorgan, 4913815739, Iran

Source: International Journal of Nanomedicine Published:2019


Abstract

Purpose: Ferulic acid (FA) is a poorly water-soluble natural antioxidant with anticancer activity. This poor solubility limits the application of FA in the food and pharmaceutical industry. Cyclodextrin nanosponges (CD-NSs) are a novel group of cross-linked CD derivatives which can be used to enhance the solubility of low-soluble bioactive compounds. Methods: In this study, FA was encapsulated into the NSs in the proportion of 1:4 (FA:NS). Diphenyl carbonate was used as a cross-linker in different proportions with β-CD. Characterization of obtained NSs was performed using scanning electron microscopy, Xray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) analysis. Results: Our results revealed that the solubility of encapsulated FA was increased up to fifteenfold compared with pure FA in the proportion of 1:4 (CD:cross-linker). The results of FTIR, XRD, and DSC confirmed the interaction of FA with NSs. The cytotoxicity of encapsulated FA against MCF7 and 4T1 breast cancer cell lines was investigated using different concentrations of FA in 24, 48, and 72 hrs. The cytotoxicity assay indicated that FA treatment reduced viability and enhanced apoptosis of cancer cells. IC50 value of encapsulated FA (250 ppm) was decreased by threefold when compared with pure FA (750 ppm). Conclusion: In general, CD-NS was found to be a suitable delivery system for poorly soluble bioactives such as FA. © 2019 Rezaei et al.
Related Docs
View other Related Docs
1. Limonene Loaded Cyclodextrin Nanosponge: Preparation, Characterization, Antibacterial Activity and Controlled Release, Food Bioscience (2021)
2. Nanoencapsulation of Hydrophobic and Low-Soluble Food Bioactive Compounds Within Different Nanocarriers, Food Hydrocolloids (2019)
3. Evaluation of the Antibacterial Activity of Encapsulated D-Limonene Inβcyclodextrin-Based Nanosponge; [ارزیابی اثر ضد باکتریایی دي لیمونن نانوانکپسوله شده در نانواسفنج بتاسیکلودکسترین], Journal of Food Science and Technology (Iran) (2023)
4. Incorporation of Thyme Essential Oil Into the Β-Cyclodextrin Nanosponges: Preparation, Characterization and Antibacterial Activity, Journal of Molecular Structure (2021)
5. Ferulic Acid Grafted Into Β-Cyclodextrin Nanosponges Ameliorates Paraquat-Induced Human Mrc-5 Fibroblast Injury, Environmental Toxicology (2024)
6. Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances, Nanomaterials (2022)
7. Loading Ferulic Acid Into Β-Cyclodextrin Nanosponges; Antibacterial Activity, Controlled Release and Application in Pomegranate Juice As a Copigment Agent, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
8. Design and Formulation of Nano/Micro-Encapsulated Natural Bioactive Compounds for Food Applications, Application of Nano/Microencapsulated Ingredients in Food Products (2020)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (10)
Masoud Sami (3)
Other Related Docs
9. Release of Bioactive Compounds From Delivery Systems by Stimuli-Responsive Approaches; Triggering Factors, Mechanisms, and Applications, Advances in Colloid and Interface Science (2022)
10. Caffeine-Loaded Nano/Micro-Carriers: Techniques, Bioavailability, and Applications, Critical Reviews in Food Science and Nutrition (2024)
11. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
12. Characterization and Investigation of Cytotoxicity and Antimicrobial Properties of Coencapsulated Limonene and Thymol Into the Ferula Assafoetida Gum Microparticles, International Journal of Biological Macromolecules (2024)
13. Transferrin-Targeted Poly(Butylene Adipate)/Terephthalate Nanoparticles for Targeted Delivery of 5-Fluorouracil in Ht29 Colorectal Cancer Cell Line, Journal of Bioactive and Compatible Polymers (2017)
14. Study of Antibacterial Performance of Synthesized Silver Nanoparticles on Streptococcus Mutans Bacteria, Nanomedicine Research Journal (2022)
15. Local Delivery of Usnic Acid Loaded Rhamnolipid Vesicles by Gelatin / Tragacanth Gum / Montmorillonite/ Vanillin Cryogel Scaffold for Expression of Osteogenic Biomarkers and Antimicrobial Activity, Journal of Drug Delivery Science and Technology (2022)
16. Biosynthesis of Lead Oxide and Cerium Oxide Nanoparticles and Their Cytotoxic Activities Against Colon Cancer Cell Line, Inorganic Chemistry Communications (2021)
17. Nanosponges: An Overlooked Promising Strategy to Combat Sars-Cov-2, Drug Discovery Today (2022)
18. 5Fu-Loaded Pcl/Chitosan/Fe3o4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System, Advanced Pharmaceutical Bulletin (2022)
19. Nanocrystalization of Pioglitazone by Precipitation Method, Drug Research (2018)
20. Biosynthesis of Core–Shell Α-Fe2o3@Au Nanotruffles and Their Biomedical Applications, Biomass Conversion and Biorefinery (2024)
21. Preparation and Characterization of Celecoxib Solid Dispersions; Comparison of Poloxamer-188 and Pvp-K30 As Carriers, Iranian Journal of Basic Medical Sciences (2014)
22. Novel Worm-Like Amphiphilic Micelles of Folate-Targeted Cyclodextrin/Retinoic Acid for Delivery of Doxorubicin in Kg-1 Cells, Colloid and Polymer Science (2014)
23. Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules, Recent Patents on Nanotechnology (2021)
24. Influence of Β - Cyclodextrin Complexation on Lovastatin Release From Osmotic Pump Tablets (Opt), Daru (2007)
25. Nanotechnology in the Formulation and Delivery of Natural Products for Cancer, Handbook of Oncobiology: From Basic to Clinical Sciences (2024)
26. Thermosensitive Folic Acid-Targeted Poly (Ethylene-Co-Vinyl Alcohol) Hemisuccinate Polymeric Nanoparticles for Delivery of Epirubicin to Breast Cancer Cells, Iranian Polymer Journal (English Edition) (2016)
27. Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods, Iranian Journal of Pharmaceutical Research (2015)
28. Promising Dissolution Enhancement Effect of Soluplus on Crystallized Celecoxib Obtained Through Antisolvent Precipitation and High Pressure Homogenization Techniques, Colloids and Surfaces B: Biointerfaces (2014)
29. Preparation of Chitosan Nanoparticles for Simultaneous Drug Delivery of Dacarbazine and Enoxaparin in Melanoma, Carbohydrate Polymers (2023)