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High Prevalence of Sars-Coronavirus-2 in Patients With Inflammatory Bowel Disease and the Role of Soluble Angiotensin Converting Enzyme2 Publisher Pubmed



Shahrokh S1 ; Baradaran Ghavami S1 ; Asadzadeh Aghdaei H1 ; Parigi TL2, 3 ; Farmani M1 ; Danese S2, 4 ; Ebrahimi Daryani N5 ; Vossoughinia H6 ; Balaii H1 ; Alborzi F5 ; Khoramjoo SM1 ; Khanabadi B1 ; Seyed Salehi A1 ; Bastani A7 Show All Authors
Authors
  1. Shahrokh S1
  2. Baradaran Ghavami S1
  3. Asadzadeh Aghdaei H1
  4. Parigi TL2, 3
  5. Farmani M1
  6. Danese S2, 4
  7. Ebrahimi Daryani N5
  8. Vossoughinia H6
  9. Balaii H1
  10. Alborzi F5
  11. Khoramjoo SM1
  12. Khanabadi B1
  13. Seyed Salehi A1
  14. Bastani A7
  15. Sharifi M8
  16. Safari MT1
  17. Malekpour H1
  18. Sherkat G9
  19. Saberafsharian M10
  20. Miri MB11
  21. Moosavi SH11
  22. Anaraki F12
  23. Nazemalhosseinimojarad E1
  24. Mohebbi SR1
  25. Shojaie S1
  26. Pourhoseingholi MA1
  27. Zali MR1
Show Affiliations
Authors Affiliations
  1. 1. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biomedical Sciences, Humanitas University, Milan, Italy
  3. 3. Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
  4. 4. IBD Center, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
  5. 5. Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
  8. 8. Isfahan University of Medical Science, Isfahan University of Medical Science, Isfahan, Iran
  9. 9. Medicine Faculty of Mashhad Branch, Islamic Azad University, Mashhad, Iran
  10. 10. Faculty of Mashhad Branch, Islamic Azad University, Mashhad, Iran
  11. 11. Department of Medical Sciences, Hormozgan University, Hormozgan, Iran
  12. 12. Colorectal division of surgrical ward, Taleghani hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2024


Abstract

Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection. Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and without IBD. We performed a cross-sectional retrospective multicenter study. Methods: We enrolled patients with IBD screened for SARS-COV-2 in six medical centres in Iran from June to November 2020. The blood samples were drawn to measure COVID-19 IgM and IgG, and serum levels of sACE2, sACE1, and interferon-α, regardless of suspicious symptoms have done the molecular test. Results: A total of 534 IBD patients were included in the study. Of these, 109 (20.0%) cases had detectable IgG and IgM against SARS-CoV-2. sACE2 levels were higher in IBD patients than controls, whereas ACE1and IFN-α levels were similar among groups. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
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